Synthesis, spectral characterization and DNA binding of Schiff-base metal complexes derived from 2-amino-3-hydroxyprobanoic acid and acetylacetone

Hosny, Nasser Mohammed; Hussien, Mostafa A.; Radwan, Fatima M.; Nawar, Nagwa

doi:10.1016/j.saa.2014.04.165

Cited by 45 publications

(19 citation statements)

References 34 publications

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“…These bands confirm the presence of the free ligand in the keto form. The ligand shows also, bands at 1605, 1306, 1199 and 971 cm -1 attributed to ν (HC=N), ν (C-O), ν (C-N) and ν (N-N), respectively [25,26]. Comparison of the IR spectrum of the ligand with that of Pt(II) complex reveals that the ligand chelates Pt(II) ion in a mono-negative bidentate mode via azomethine nitrogen (C=N) and the enolized carbonyl oxygen after displacement of hydrogen ( Molecular mechanics method was used to predict rapidly the geometries of the two suggested conformers by using hyperchem series of programs [30].…”

Section: Ir Spectra Of the Ligand And Its Pt(ii) Complexmentioning

confidence: 99%

Synthesis, Characterization and Cytotoxic Activity of N-(5-indanyl(methylene)anthranilic acid(5-indanyl methylene)-hydrazide and Its Pt(II) Complex

Hosny

Barakat

2019

AJRB

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Since the discovery of the platinum based complex, cisplatin, medicinal inorganic chemistry has attracted much more attention and a large number of platinum complexes with promising pharmacological properties have been synthesized. In this work a new platinum complex of N-(5-indanyl(methylene)anthranilic acid(5-indanyl methylene)-hydrazide (HL) has been synthesized and characterized by physical and spectral techniques, as elemental analysis, IR, EI-MS, 1H-NMR, thermal analysis, transmittance electron microscope (TEM) and magnetic moment. The results indicated that the ligand binds to Pt(II) in the enol form. Square-planar stereochemistry was suggested for the Pt(II) complex. The morphological characterization showed nano-sized spherical particles with average size 92 nm of the isolated complex. The synthesized Pt(II) complex exhibited a significant cytotoxic activity against HCT116 and HEPG2. Also in vivo study of the Pt(II) complex showed cytotoxic activity towards Ehrlich ascites carcinoma (EAC).

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Section: Ir Spectra Of the Ligand And Its Pt(ii) Complexmentioning

confidence: 99%

Synthesis, Characterization and Cytotoxic Activity of N-(5-indanyl(methylene)anthranilic acid(5-indanyl methylene)-hydrazide and Its Pt(II) Complex

Hosny

Barakat

2019

AJRB

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“…The highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) of [MoO 2 (Sal-Tryp)EtOH] complex are shown in Figure 4. The energy gap or E HOMO − E LUMO , an important stability index in characterizing the chemical reactivity and kinetic stability of a molecule, [51][52][53] is 0.11 au. Moreover, the 1 H NMR chemical shifts obtained for [MoO 2 (Sal-Tryp)EtOH] complex via calculation [54] have been compared to those obtained experimentally (Table S4, supporting information).…”

Section: Molecular Orbital Analysismentioning

confidence: 99%

Synthesis, characterization, density functional theory studies and antibacterial activity of a new Schiff base dioxomolybdenum(VI) complex with tryptophan as epoxidation catalyst

Asgharpour

Farzaneh

Ghiasi

et al. 2017

Applied Organom Chemis

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A cis-dioxomolybdenum(VI) complex was prepared with MoO 2 (acac) 2 and a Schiff base ligand (2-((2-hydroxybenzylidene)amino)-3-(1H-indol-3-yl)propanoic acid) derived from salicylaldehyde and L-tryptophan in ethanol and designated as [MoO 2 (Sal-Tryp)(EtOH)]. It was characterized using several techniques including thermogravimetric and elemental analyses and mass, Fourier transform infrared and UV-visible spectroscopies. Theoretical calculations were performed using density functional theory for studying the molecular structure. An in vitro antibacterial activity evaluation showed that [MoO 2 (Sal-Tryp)EtOH] complex exhibits good inhibitory effects against Gram-positive (Bacillus subtilis, Staphylococcus aureus) and Gram-negative (Escherichia coli, Pseudomonas aeruginosa) bacteria in comparison to standard antibacterial drugs. It was also found that [MoO 2 (Sal-Tryp) EtOH] complex successfully catalyses the epoxidation of cyclooctene, norbornene, cyclohexene, styrene, α-methylstyrene and trans-stilbene, with 45-100% conversions and 64-100% selectivities. Based on the obtained results, the heterogeneity and reusability of the catalyst seem promising.

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“…The intermediate steps for all four complexes appear to represent the decomposition of the ligand to different organic moieties. 2,10 Electronic spectra and magnetic moments…”

Section: Mass Spectra Of the Complexesmentioning

confidence: 99%

“…The enol form of Schiff bases of mono-and diamines have attracted much attention because of their advantages, such as ease of synthesis and the presence of variety of coordination sites that make them invaluable in coordination chemistry. 1,2 Schiff base complexes have many applications, e.g., they are used as catalyst in oxygenation, decomposition, electro-reduction and hydrolysis reactions. 3,4 Schiff bases of β-diketones stabilize different metals in various oxidation states in many useful catalytic transformations.…”

Section: Introductionmentioning

confidence: 99%

Spectral, thermal, optical and biological studies on (E)-4-[(2-hydroxyphenyl)imino]pentan-2-one and its complexes

2016

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Metal complexes derived from the reaction of Cu(II), Co(II), Ni(II) and Zn(II) acetates and (E)-4-[(2-hydroxyphenyl)imino]pentan-2-one (H 2 L) were synthesized and characterized by elemental analyses, MS, IR, UV-Vis and 1 H-NMR spectroscopy, thermogravimetry (TG) and differential TG (DTG), and magnetic measurements. In all complexes except for the Zn(II) complex, the Schiff base ligand acts as a mono-negative tridentate (NOO) donor, through the azomethine nitrogen, the hydroxyl oxygen and the enolic carbonyl oxygen. The structure of the Cu(II) complex is square planar, the Co(II) is octahedral while, the Ni(II) and Zn(II) are tetrahedral. Optical band gap measurements indicated the semi-conducting nature of these complexes. The biological activities were screened against two bacteria and two fungi. Some of the studied complexes showed activity against bacteria and fungi.

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Synthesis, spectral characterization and DNA binding of Schiff-base metal complexes derived from 2-amino-3-hydroxyprobanoic acid and acetylacetone

Cited by 45 publications

References 34 publications

Synthesis, Characterization and Cytotoxic Activity of N-(5-indanyl(methylene)anthranilic acid(5-indanyl methylene)-hydrazide and Its Pt(II) Complex

Synthesis, Characterization and Cytotoxic Activity of N-(5-indanyl(methylene)anthranilic acid(5-indanyl methylene)-hydrazide and Its Pt(II) Complex

Synthesis, characterization, density functional theory studies and antibacterial activity of a new Schiff base dioxomolybdenum(VI) complex with tryptophan as epoxidation catalyst

Spectral, thermal, optical and biological studies on (E)-4-[(2-hydroxyphenyl)imino]pentan-2-one and its complexes

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