Synthesis, spectral characterization and DNA interactions of 5-(4-substituted phenyl)-1,3,4-thiadiazol-2-amine scaffolds

Highly sensitive pork meat detection using copper(ii) tetraaza complex by electrochemical biosensor

“…In this case, complex 2b favourably interacts with DNA compared to complex 1a and 2a. The magnitude of Stern Volmer quenching constant for complexes 1a , 2a and 2b were similar to the non-intercalator compounds, which interact electrostatically with DNA. 30,32,36,37…”

“…For comparison, the complexes that interact with DNA electrostatically have intrinsic binding constant K b in the range of 2.5 × 10 4 M −1 to 8.5 × 10 4 M −1 . [29][30][31][32][33] These complexes' binding strengths at magnitude 10 4 are identical to complexes 1a, 2a, and 2b. Hence, the complexes clearly bind to DNA by electrostatic mode.…”

“…The magnitude of Stern Volmer quenching constant for complexes 1a, 2a and 2b were similar to the non-intercalator compounds, which interact electrostatically with DNA. 30,32,36,37 3.2.3. Viscosity measurements.…”

Bivalent Ni(II), Co(II) and Cu(II) complexes of [(E)-[(2-methyl-1,3-thiazol-5-yl)methylidene]amino]thiourea: synthesis, spectral characterization, DNA and in-vitro anti-bacterial studies

“…A decrease or increase in fluorescence intensity ( Figure 9 (i)) has been observed in fluorescence EB displacement experiments conducted in Tris-HCl buffer solution while enhancing the metal complexes concentration. Tris- HCl buffer solution (pH,7.2) is used in these experiments since EB is non-emissive because of quenching of free EB by the solvent molecules [ 56 ]. The Stern –Volmer quenching constant K sv value was computed using the classical Stern-Volmer Eq.…”

New 1,3,4-thiadiazoles as potential anticancer agents: pro-apoptotic, cell cycle arrest, molecular modelling, and ADMET profile

“…The separated solid was ltered off, dried, and recrystallized from ethanol affording compounds 9 and 10, respectively. (9) 2.1.17 General procedure for the synthesis of compounds (11)(12)(13)(14)(15)(16). 1,3,4-Thiadiazole derivative 3 (2.8 g, 10 mmol) was added to a cold suspension of nely divided potassium hydroxide (0.56 g, 10 mmol) in DMF (15 mL) with stirring for 30 minutes.…”