Synthesis, spectral characterization of some new 3-heteroaryl azo 4-hydroxy coumarin derivatives and their antimicrobial evaluation

Sahoo, Jagannath; Mekap, Suman Kumar; Kumar, Pankaj

doi:10.1016/j.jtusci.2014.08.001

Cited by 72 publications

(28 citation statements)

References 19 publications

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“…Many coumarins are synthesized in the lab and used as medicines for humans and animals. In this sense, coumarin-1,2,3triazole conjugate and 3-heteroarylazo 4-hydroxy showed bactericidal action against Enterococcus faecalis [80] and Staphylococcus aureus, Escherichia coli, Bacillus subtilis, and Pseudomonas aeruginosa [69], respectively ( Table 1).…”

Section: Coumarinsmentioning

confidence: 98%

Role of Herbs and Medicinal Spices as Modulators of Gut Microbiota

Martínez¹,

Más²

2020

Herbs and Spices

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Currently, herbs, medicinal spices, green medicine, or traditional Chinese medicine has gained many followers in the world, especially as a way of life and as an alternative to the indiscriminate use of synthetic medicines such as antibiotics. These natural products are rich in secondary metabolites or phytochemicals, which are chemical compounds of relatively complex structures and restricted distribution; these compounds have defensive functions against insects, bacteria, fungi, parasites, and viruses. Likewise, several studies have shown their effectiveness in the prevention and treatment of several diseases such as cancer, autoimmune diseases, gastrointestinal diseases, diabetes, neurodegenerative diseases, Crohn's disease, and human immunodeficiency virus (HIV), among others. In addition, this review addresses the mechanisms of action of the herbs and medicinal spices on intestinal microbiota, increasing competitive exclusion in the intestinal membrane and inhibiting bacterial translocation and damage to the intestinal barrier.

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Section: Coumarinsmentioning

confidence: 98%

Role of Herbs and Medicinal Spices as Modulators of Gut Microbiota

Martínez¹,

Más²

2020

Herbs and Spices

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“…Many authors have published researches exploring the medicinal properties of coumarins [4,6,12,[35][36][37]. Coumarins possess antimicrobial activity such as antibacterial [38][39][40][41][42][43][44] and antifungal [40,[45][46][47][48]. Numerous coumarin derivatives showed significant antioxidant activity [49][50][51][52][53].…”

Section: Introductionmentioning

confidence: 99%

“…Further reactions were carried out between various phenol derivatives and ethyl 3,3-diethoxypropionate afforded products in poor to high yields (< 5-90%). Sahoo et al reported synthesis of 4-hydroxy-3-(hetero aryl Azo) coumarins [43]. Initially, 4hydroxy coumarin was synthesized via Claisen condensation of 2-hydroxy acetophenone and diethyl carbonate, in the presence of sodium hydride in toluene.…”

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confidence: 99%

Recent Advances in the Synthesis of Coumarin Derivatives from Different Starting Materials

et al. 2020

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The study of coumarin dates back to 1820 when coumarin was first extracted from tonka bean by Vogel. Compounds containing coumarin backbone are a very important group of compounds due to their usage in pharmacy and medicine. Properties and biological activities of coumarin derivatives have a significant role in the development of new drugs. Therefore, many different methods and techniques are developed in order to synthesize coumarin derivatives. Coumarin derivatives could be obtained from different starting materials with various methods but with big differences in yield. This review summarized various methods, techniques and reaction conditions for synthesis of coumarins from different compounds such as aldehydes, phenols, ketones and carboxylic acids.

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“…It had been reported that azo‐ compounds exhibit interesting biological activities such as in‐vitro antimicrobial activity. [ 3 ] In general, azo‐ compounds exhibit good antibacterial activity against Gram‐positive bacteria such as Staphylococcus aureus but they are inactive against Gram‐negative bacteria such as Pseudomonas aeruginosa . [ 4 ] This behavior is attributed to the structural similarity of azo‐ compounds with stilbenes, and so, they could share the same mechanism of action.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, in‐vitro and in‐silico study of novel thiazoles as potent antibacterial agents and MurB inhibitors

Sanad

Ahmed

Mekky

2020

Archiv der Pharmazie

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Efficient procedures are herein reported for the synthesis of novel hybrid thiazoles via a one‐pot three‐component protocol. The protocol involves the reaction of novel aldehyde, thiosemicarbazide and halogen‐containing reagents in solvent‐ and catalyst‐free conditions. The structures of the new thiazoles were elucidated by elemental analyses and spectroscopic data. The in‐vitro antibacterial screening and MurB enzyme inhibition assays were performed for the novel thiazoles. The thiazol‐4(5H)‐one derivative 6d, with p‐MeO, exhibits the best antibacterial activities with minimum inhibitory concentration values of 3.9, 3.9, 7.8, and 15.6 μg/ml against Staphylococcus aureus, Klebsiella pneumoniae, Streptococcus mutans, and Escherichia coli, respectively, as compared to the reference antibiotic drugs. It also exhibits the highest inhibition of the MurB enzyme with an IC50 of 8.1 μM. The structure–activity relationship was studied to determine the effect of the structures of the newly prepared molecules on the strength of the antibacterial activities. Molecular docking was also performed to predict the binding modes of the new thiazoles in the active sites of the E. coli MurB enzyme.

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Synthesis, spectral characterization of some new 3-heteroaryl azo 4-hydroxy coumarin derivatives and their antimicrobial evaluation

Cited by 72 publications

References 19 publications

Role of Herbs and Medicinal Spices as Modulators of Gut Microbiota

Role of Herbs and Medicinal Spices as Modulators of Gut Microbiota

Recent Advances in the Synthesis of Coumarin Derivatives from Different Starting Materials

Synthesis, in‐vitro and in‐silico study of novel thiazoles as potent antibacterial agents and MurB inhibitors

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