Synthesis, spectral, electrochemical and biological studies of Co(II), Ni(II) and Cu(II) complexes with Schiff bases of 8-formyl-7-hydroxy-4-methyl coumarin

Kulkarni, Ajaykumar D.; Avaji, Prakash Gouda; Bagihalli, Gangadhar B.; Patil, Sangamesh A.; Badami, Prema S.

doi:10.1080/00958970802226387

Cited by 88 publications

(33 citation statements)

References 18 publications

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“…The antibacterial studies showed that all three complexes are more active against E. coli than the free ligand [32,33]. It is suspected that factors such as solubility, conductivity, dipole moment and cell permeability may be the possible reasons for the increase in activity [34].…”

Section: In Vitro Antimicrobial Assaymentioning

confidence: 96%

Synthesis, characterization and biological activity studies of octahedral nickel(II) complexes

Patel

Singh

Shukla

et al. 2011

Transition Met Chem

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Three nickel(II) complexes, namely [Ni(BH) 3 ]-(H 2 O)(NO 3 )(ClO 4 ) 1, [Ni(BH) 2 (NO 3 ) 2 ] 2 and [Ni(BH)-(Tren)](ClO 4 ) 2 3 (BH = Benzoylhydrazine, Tren = Tris(2-aminoethyl)amine) have been synthesized and characterized by physico-chemical techniques. X-ray crystallographic analysis shows the nickel to be six-coordinated in these complexes. The complexes are efficient catalysts for the dismutation of superoxide in alkaline DMSO-NBT assays. The IC 50 values are 74,108 and 105 lM for 1, 2 and 3, respectively.

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Section: In Vitro Antimicrobial Assaymentioning

confidence: 96%

Synthesis, characterization and biological activity studies of octahedral nickel(II) complexes

Patel

Singh

Shukla

et al. 2011

Transition Met Chem

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“…The antifungal activity of synthesized Schiff bases and some of their complexes was close to that of the standard drug fluconazole (Table 4). It has been reported in the past that metal complexes with Schiff bases of formyl coumarin derivatives possess high antimicrobial activity 17,18,23,[42][43][44] . The minimum inhibitory concentration (MIC) of some selected compounds, which showed significant activity against selected bacterial and fungi species, was also determined, and results are presented in Table 5.…”

Section: In Vitro Antibacterial and Antifungal Activitymentioning

confidence: 99%

DNA cleavage and in vitro antimicrobial studies of Co(II), Ni(II), and Cu(II) complexes with ONNO donor Schiff bases: Synthesis, spectral characterization, and electrochemical studies

Kulkarni

Patil

Badami³

2009

Journal of Enzyme Inhibition and Medicinal Chemistry

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A series of Co(II), Ni(II), and Cu(II) complexes of the type ML.2H 2 O have been synthesized with Schiff bases derived from 8-formyl-7-hydroxy-4-methylcoumarin and o-phenylenediamine/ethylenediamine. The structure of the complexes has been proposed in the light of analytical, spectral (IR, UV-Vis, ESR, and FAB-mass), magnetic, thermal, and fluorescence studies. The complexes are soluble in DMF and DMSO. The measured molar conductance values indicate that the complexes are non-electrolytes in nature. In view of IR, UV-Vis, and magnetic studies, it has been concluded that all the complexes possess octahedral geometry, in which ligand is coordinated to metal ion through the azomethine nitrogen and phenolic oxygen via deprotonation. Thermal studies provide useful information about the coordination of water molecules to the metal ion and the stability of the complexes. The redox behavior of the complexes has been investigated by an electrochemical method using cyclic voltammetry. The Schiff bases and their metal complexes have been screened for their antibacterial (Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Salmonella typhi) and antifungal activities (Aspergillus niger, Aspergillus flavus, and Cladosporium) by the minimum inhibitory concentration method. DNA binding with Co(II) and Cu(II) complexes has been studied by the agarose gel electrophoresis method.

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“…The molar conductance of 10 −3 M solutions of the complexes soluble in DMSO was measured at room temperature on a Eutech Con 510 Conductivity meter. 1 ligands were recorded in DMSO-d6 on a JEOL AL-300 FT-NMR multinuclear spectrometer. Chemical shifts were reported in parts per million (ppm) using tetramethylsilane as an internal standard.…”

Section: Physico-chemical Measurementsmentioning

confidence: 99%

“…Acylhydrazones of various aldehydes and ketones occupy a special place among the biologically important organic ligands containing a variety of donor groups 1 . These Schiff bases are able to change their coordination behaviour depending on the starting reagents, pH of the medium and reaction conditions.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and biocidal activity of some transition metal(II) complexes with isatin salicylaldehyde acyldihydrazones

Singh

2011

Journal of Enzyme Inhibition and Medicinal Chemistry

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Synthesis, spectral, electrochemical and biological studies of Co(II), Ni(II) and Cu(II) complexes with Schiff bases of 8-formyl-7-hydroxy-4-methyl coumarin

Cited by 88 publications

References 18 publications

Synthesis, characterization and biological activity studies of octahedral nickel(II) complexes

Synthesis, characterization and biological activity studies of octahedral nickel(II) complexes

DNA cleavage and in vitro antimicrobial studies of Co(II), Ni(II), and Cu(II) complexes with ONNO donor Schiff bases: Synthesis, spectral characterization, and electrochemical studies

Synthesis, characterization and biocidal activity of some transition metal(II) complexes with isatin salicylaldehyde acyldihydrazones

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