Synthesis, spectral properties and reactions of the novel dinuclear alkyne complexes [M(μ-I)I(CO)(NCMe)(η2-PhC2R)]2 (M = Mo or W, R = Ph or Me)

Baker, Paul K.; Keys, Elaine M.

doi:10.1016/s0277-5387(00)81398-4

Cited by 8 publications

(1 citation statement)

References 9 publications

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“…In particular, the elastic modulus measured with nanoindentation has been shown to increase with the degree of mineralization of bone tissue [28][29][30]. Interestingly, nanoindentation has been used to investigate bone tissue properties around implants [12,13,[31][32][33][34], but it was not possible to clearly relate the indentation modulus with the nature (mature or newly formed) of bone tissue. Moreover, the relationship between healing time and mechanical properties of bone tissue remains unknown.…”

Section: Nanoindentation Measurements Of Biomechanical Properties In mentioning

confidence: 99%

Nanoindentation Measurements of Biomechanical Properties in Mature and Newly Formed Bone Tissue Surrounding an Implant

Vayron

Barthel

Mathieu

et al. 2012

Journal of Biomechanical Engineering

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The characterization of the biomechanical properties of newly formed bone tissue around implants is important to understand the osseointegration process. The objective of this study is to investigate the evolution of the hardness and indentation modulus of newly formed bone tissue as a function of healing time. To do so, a nanoindentation device is employed following a multimodality approach using histological analysis. Coin-shaped implants were placed in vivo at a distance of 200 μm from the cortical bone surface, leading to an initially empty cavity of 200 μm * 4.4 mm. Three New Zealand White rabbits were sacrificed after 4, 7, and 13 weeks of healing time. The bone samples were embedded and analyzed using histological analyses, allowing to distinguish mature and newly formed bone tissue. The bone mechanical properties were then measured in mature and newly formed bone tissue. The results are within the range of hardness and apparent Young's modulus values reported in previous literature. One-way ANOVA test revealed a significant effect of healing time on the indentation modulus (p < 0.001, F = 111.24) and hardness (p < 0.02, F = 3.47) of bone tissue. A Tukey-Kramer analysis revealed that the biomechanical properties of newly formed bone tissue (4 weeks) were significantly different from those of mature bone tissue. The comparison with the results obtained in Mathieu et al. (2011, "Micro-Brillouin Scattering Measurements in Mature and Newly Formed Bone Tissue Surrounding an Implant," J. Biomech. Eng., 133, 021006). shows that bone mass density increases by approximately 13.5% between newly formed bone (7 weeks) and mature bone tissue.

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Section: Nanoindentation Measurements Of Biomechanical Properties In mentioning

confidence: 99%

Nanoindentation Measurements of Biomechanical Properties in Mature and Newly Formed Bone Tissue Surrounding an Implant

Vayron

Barthel

Mathieu

et al. 2012

Journal of Biomechanical Engineering

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Mo(CO)₂(PPh₃)₂(O₃SCF₃)₂: Ein neuer Vorläufer einer dikationischen, metallorganischen Lewis‐Säure mit drei freien Koordinationsstellen

Rosendorfer¹,

Beck²

1995

Chem. Ber.

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Organometallic Lewis Acids, LIVtOl. -M O ( C O )~( P P~~)~( O~S C F~)~: A New Precursor for an Organometallic Dicationic Lewis Acid with Three Accessible Coordination Sites The reaction of Mo(COj2(PPh3j2Br, (1) with Ag03SCF3 gives 1-propyne leads to the monoalkyne complexes Mo(C0)the bis(trif1ate) complex M o ( C O )~( P P~~)~( O~S C F~)~ (3) which (MeC=CR)(PPh3)2(03SCF3)2 (9: R = Me; 10: R = Ph) in mocan be considered as a precursor for the 12-e-system "Mo-derate yield. In contrast, the bisalkyne complexes [M(CO)-(C0)2(PPh3)$+". According to the spectroscopic data one of (MeC=CMe),(PPh3)2(03SCF3)][CF3S03] (1 1: M = Mo; 12: the two coordinated CF3SO; anions is acting as a chelate M = W) are formed in high yield when a CH2C12 solution of ligand. Treatment of 3 and of the in situ generated W(CO)2-2-butyne is added to 1 and 2 in the presence of Ag03SCF3. (PPh3)2(03SCF3)2 (4) with H 2 0 affords the dinuclear hydroxo-At room temperature, 11 and 12 are highly fluxional in solubridged complexes [M2(p-OH)3(CO),(PPh3)4][CF3S03] (5: tion, while 9 and 10 are stereochemically rigid. Treatment of M = Mo; 6: M = W). Acetonitrile replaces the CF3S0y li-11 with acetonitrile yields [Mo(CO)(MeC=CMe),(PPh,),gands in 3 and 4 to afford the cationic complexes (NCMe)][CF3S03]2 (13). Compounds 3-13 (except 4) are [M(CO)2(PPh3)2(NCMe)3][CF3S03]2 (7: M = Mo; 8: M = W). characterized by IR, 'H-, 13C-, 19F-, and 31P-NMR spectros-The reaction of 3 with an excess of 2-butyne and 1-phenyl-copy.

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Structural Mimics of Acetylene Hydratase: Tungsten Complexes Capable of Intramolecular Nucleophilic Attack on Acetylene

Vidovič

Peschel

Buchsteiner

et al. 2019

Chemistry A European J

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Bioinspired complexes employing the ligands 6‐tert‐butylpyridazine‐3‐thione (SPn) and pyridine‐2‐thione (SPy) were synthesized and fully characterized to mimic the tungstoenzyme acetylene hydratase (AH). The complexes [W(CO)(C2H2)(CHCH‐SPy)(SPy)] (4) and [W(CO)(C2H2)(CHCH‐SPn)(SPn)] (5) were formed by intramolecular nucleophilic attack of the nitrogen donors of the ligand on the coordinated C2H2 molecule. Labelling experiments using C2D2 with the SPy system revealed the insertion reaction proceeding via a bis‐acetylene intermediate. The starting complex [W(CO)(C2H2)(SPy)2] (6) for these studies was accessed by the new acetylene precursor mixture [W(CO)(C2H2)n(MeCN)3−nBr2] (n=1 and 2; 7). All complexes represent rare examples in the field of W−C2H2 chemistry with 4 and 5 being the first of their kind. In the ongoing debate on the enzymatic mechanism, the findings support activation of acetylene by the tungsten center.

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Synthesis, spectral properties and reactions of the novel dinuclear alkyne complexes [M(μ-I)I(CO)(NCMe)(η2-PhC2R)]2 (M = Mo or W, R = Ph or Me)

Cited by 8 publications

References 9 publications

Nanoindentation Measurements of Biomechanical Properties in Mature and Newly Formed Bone Tissue Surrounding an Implant

Nanoindentation Measurements of Biomechanical Properties in Mature and Newly Formed Bone Tissue Surrounding an Implant

Mo(CO)₂(PPh₃)₂(O₃SCF₃)₂: Ein neuer Vorläufer einer dikationischen, metallorganischen Lewis‐Säure mit drei freien Koordinationsstellen

Structural Mimics of Acetylene Hydratase: Tungsten Complexes Capable of Intramolecular Nucleophilic Attack on Acetylene

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Synthesis, spectral properties and reactions of the novel dinuclear alkyne complexes [M(μ-I)I(CO)(NCMe)(η2-PhC2R)]2 (M = Mo or W, R = Ph or Me)

Cited by 8 publications

References 9 publications

Nanoindentation Measurements of Biomechanical Properties in Mature and Newly Formed Bone Tissue Surrounding an Implant

Nanoindentation Measurements of Biomechanical Properties in Mature and Newly Formed Bone Tissue Surrounding an Implant

Mo(CO)2(PPh3)2(O3SCF3)2: Ein neuer Vorläufer einer dikationischen, metallorganischen Lewis‐Säure mit drei freien Koordinationsstellen

Structural Mimics of Acetylene Hydratase: Tungsten Complexes Capable of Intramolecular Nucleophilic Attack on Acetylene

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Mo(CO)₂(PPh₃)₂(O₃SCF₃)₂: Ein neuer Vorläufer einer dikationischen, metallorganischen Lewis‐Säure mit drei freien Koordinationsstellen