Synthesis, spectroscopic characterization and antiproliferative activity of two platinum(II) complexes containing N-donor heterocycles

Palladium(II) Complexes of Ambidentate and Potentially Cyclometalating 5‐Aryl‐3‐(2′‐pyridyl)‐1,2,4‐triazine Ligands

“…The 5‐aryl‐3‐(2′‐pyridyl)‐1,2,4‐triazine moieties themselves have been used for decades as versatile ligands for transition‐metal complexes with some medical or technical applications. The most important application is probably that of 3‐(2‐pyridyl)‐5,6‐diphenyl‐1,2,4‐triazine‐ p , p′ ‐disulfonic acid [PyTZ(HO 2 SOPh) 2 ], following the nomenclature in Scheme , also called FerroZine™, for the colorimetric detection of Fe II in biological or other systems .…”

“…Another important application is the use of the potentially tri‐, tetra‐ or pentadentate 2,6‐bis(5,6‐dipyridyl‐1,2,4‐triazinyl)pyridine ligands for the extraction of lanthanides or actinides . Interestingly, complexes of 3‐(2′‐pyridyl)‐1,2,4‐triazine ligands with Group 10 elements are scarce . This is strange, since the abovementioned triazinyl‐containing polypyridine ligands are especially attractive for masking the corrosion and fission products Ni II and Pd II in the extraction of actinides, for example, in the PUREX process,, , and Pt II complexes of 3‐(2′‐pyridyl)‐1,2,4‐triazine ligands have been studied for their cytotoxic or antiviral properties .…”

“…Interestingly, complexes of 3‐(2′‐pyridyl)‐1,2,4‐triazine ligands with Group 10 elements are scarce . This is strange, since the abovementioned triazinyl‐containing polypyridine ligands are especially attractive for masking the corrosion and fission products Ni II and Pd II in the extraction of actinides, for example, in the PUREX process,, , and Pt II complexes of 3‐(2′‐pyridyl)‐1,2,4‐triazine ligands have been studied for their cytotoxic or antiviral properties . Very recently, the binuclear complex [Pd 2 (NO 3 ) 4 (C9BTBP)] · 2.5H 2 O {C9BTBP = 6,6′‐bis[5,6‐di(nonyl)‐1,2,4‐triazin‐3‐yl]‐2,2′‐bipyridine} was synthesised and characterised by elemental analysis, DSC‐TGA and 1 H NMR spectroscopy in a report dedicated to the separation of Pd II from minor actinides .…”

Anti-proliferative effect of Fe(III) complexed with 1-(2-hydroxy-3-methoxybenzaldehyde)-4-aminosalicylhydrazone in HepG2 cells

“…Therefore, HMB-ASH-Fe(III) complexes may have selective and pronounced activity against HepG2 cells. To date, several metal complexes containing Co(II), Ni(II), Zn(II), Pt(II), Ru(II), Sn(II), or Cu(II) have shown anti-proliferative effects in HepG2 cells (Alexandrova et al 2012;Chen et al 2013;Dyakova et al 2014;Farag et al 2013;Mahmudov et al 2014;Rubino et al 2014;Tan et al 2009;Thati et al 2007). This is the first report of HepG2 cell growth inhibition using complexes chelating the transition metal, Fe(III).…”

Synthesis of platinum complexes with 2-(5-perfluoroalkyl-1,2,4-oxadiazol-3yl)-pyridine and 2-(3-perfluoroalkyl-1-methyl-1,2,4-triazole-5yl)-pyridine ligands and their in vitro antitumor activity

“…This activity has been attributed to their DNA-binding properties [22]. In the same way, triazole rings have been widely studied as bioactive moieties [23] and also have been used as ligands in order to synthesize cytotoxic platinum, palladium and organotin(IV) complexes [24][25][26][27].…”