Synthesis, spectroscopic characterization and DNA binding studies of Cu(II) complex of Schiff base containing benzothiazole moiety

Abstract

A Schiff base ligand L has been synthesized by the condensation of thiophene-2-carbaldehyde and 2-amino-6-methylbenzothiazole. It has been characterized by elemental analysis, Infrared (IR), 1 H NMR and mass spectrometry. Copper (II) complex, ML 2 has been synthesized by the reacting ligand L and Copper (II) acetate in 2:1 molar ratio. The Cu(II) complex was characterized by elemental analysis, molar conductance, electronic spectrum, IR and electronic paramagnetic resonance spectrum. TGA has been done to check the thermal stablity of Cu(II) complex. Spectroscopic studies revealed that ligand L binds with the Cu(II) ion as bidentate fashion. On the basis of spectral studies, a distored octahedral geometry has been assigned for Cu(II) complexof ligand L. The DNA binding studies of Cu(II) complex ML 2 have been investigated by UV-vis absorption and fluorescence spectroscopy. The binding mode of ML 2 with CT-DNA could be assigned as intercalation of the metal complex between DNA base pairs.

New heterocyclic Schiff base‐metal complex: Synthesis, characterization, density functional theory study, and antimicrobial evaluation

“…[ 27 ] This suggests that the distorted octahedral geometry for Cu (II) complex of Schiff base ligand L and acetate ion. [ 28 ]…”

Evaluation of the Eff ectiveness of the Copper (II) Complex with a New Ligand derived from Benzothiazole and Anthranilic Acid as Anticancer and Antioxidant

“…Researchers were drawn to benzothiazole derivatives because of their wide range of biological activity Researchers have been drawn to schiff base because of its wide spectrum of pharmacological actions, which include antibacterial and antioxidant properties The activity of benzothiazoles against MCF-7 breast cancer cell lines is well-recognized. The epidermal growth factor receptor (EGFR) 4 is well-known for its high levels of expression, malignancies of the breast, colon, and bladder. Several researches has shown that the benzothiazole moiety and its derivatives can create the uncommon and important lead chemical.…”