2012
DOI: 10.1016/j.cclet.2012.01.025
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Synthesis, spectroscopic characterization and in vitro antitumor activities of some novel mononuclear Ru(II) complexes

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Cited by 4 publications
(4 citation statements)
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“…The in vitro antineoplastic activities of the synthesized compounds against the human cancer T-lymphocyte cell lines molt 4/C8 and CEM and the murine tumour leukaemia cell lines L1210, human oral epidermoid carcinoma KB cells, human promyelocytic leukaemia cells (HL60) and bel-7402 liver cancer cells were evaluated by the standard MTT assay (Karki, et al, 2007;Thota et al, 2012). As described in Table 2, compounds 8c and 8d exhibit very potent anticancer activity against all the cell lines.…”
Section: -Acetyl Coumarin (3) (7)mentioning
confidence: 99%
“…The in vitro antineoplastic activities of the synthesized compounds against the human cancer T-lymphocyte cell lines molt 4/C8 and CEM and the murine tumour leukaemia cell lines L1210, human oral epidermoid carcinoma KB cells, human promyelocytic leukaemia cells (HL60) and bel-7402 liver cancer cells were evaluated by the standard MTT assay (Karki, et al, 2007;Thota et al, 2012). As described in Table 2, compounds 8c and 8d exhibit very potent anticancer activity against all the cell lines.…”
Section: -Acetyl Coumarin (3) (7)mentioning
confidence: 99%
“… 42 Notably, the pyrazoline-thioamides coordinated to Ru(II) scaffolds XI possessed cytotoxic activity at sub-micromolar concentration ( Chart 1 ). 43 …”
Section: Introductionmentioning
confidence: 99%
“…42 Notably, the pyrazolinethioamides coordinated to Ru(II) scaffolds XI possessed cytotoxic activity at sub-micromolar concentration (Chart 1). 43 Coordination of ruthenium scaffolds containing orthosubstituted phenanthroline-type ligands ([Ru(dmphen) 2 ] 2+ ; dmphen is 2,9-dimethyl-1,10-phenanthroline) led to the identification of complexes with cytotoxicity toward cancer cells at micromolar concentrations. 44−59 This scaffold exhibits an intrinsically distorted octahedral geometry, and when explored for PDT or PACT applications, some of the complexes exhibited sub-micromolar anticancer activity via light-mediated ligand release and covalent binding to DNA.…”
Section: Introductionmentioning
confidence: 99%
“…The biological properties of the TSC ligands can be modified and improved by the linkage to transition metal ions [9]. Ruthenium complexes of diimine ligands such as 2,2'-bipyridine (bpy) and 1,10-phenanthroline (phen) are widely used in bioinorganic chemistry as anticancer agents [10][11][12][13][14] and a few studies have been carried out on the anticancer activity of ruthenium(II) polypyridyl complexes [15][16][17][18][19], but many more studies need to be undertaken to develop a novel and interesting group of antitumor transition metal complexes. The design, synthesis and reactivity of novel ruthenium complexes have become the central focus of research in several laboratories, including ours.…”
Section: Introductionmentioning
confidence: 99%