Synthesis, spectroscopic characterization and <i>in vitro</i> antibacterial activity studies of Cu(II) complexes derived from 6- hydroxyflavone Schiff bases

Abstract

This study reported the synthesis of the ligands (E) chromen-6-o1 (L 1) and (E)-2-((6 (L 2). These two Schiff base ligands were synthesized by refluxing e hydroxyflavone with 2-aminophenol and 2 synthesized Schiff bases were subsequently reacted with Cu(II) acetate to form the corresponding metal complexes C 1 and C 2. The compounds melting point and decomposition temperature studies, solubility test, magnetic susceptibility studies and gravimetric analysis. The purity of the compounds were analysed using TLC. The spectroscopic data indicated that the Schiff base ligands acted as tridentate and coordinated to the metal via imine nitrogen and deprotonated phenolic oxygen atoms. The Schiff base ligands have melting point between 166-185 o 202 o C. Magnetic susceptibility studies showed that the complexes are paramagnetic in nature with the µ eff values are in the range of 1.9 found to be in the range of 20.4 nature. The solubility test of the compounds indicated that they are soluble in most organic solvents except water, acetone and tetrachloro methane in which are completely insoluble. The Cu(II) acetate, synthesized ligands and their metal complexes were studied for their in vitro antibacterial activity against two gram positive bacteria (Staphylococcus aureus and Bacillus subtilis) and two gram negative bacteria (Escherichia coli and Salmonel diffusion method and the results indicated that the complexes were more active than the ligands and the Cu(II) acetate but less active compared to standard drug (ciprofloxacin). Keywords: 6-hydroxyflavone, 2-aminophenol, 2 activity. compounds (Refat et al., 2013), perhaps due to biochemical and antimicrobial properties. Copper(II)

Fruit palm peel extract derived from supercritical CO2 extraction as a potent source of bioactive compounds

“…The micrographs were recorded at a medium magnification of 1000 x 100 µm. The sample extract was subjected to infrared spectral analysis within the range of 4000 -650 cm -1 according to a procedure reported by Bello et al [12], using Cary 630 Agilent Technologies.…”

Investigating the Effect of Cyclodextrin Nanosponges and Cyclodextrin-Based Hydrophilic Polymers on the Chemical Pharmaceutical and Toxicological Profile of Al(III) and Ga(III) Complexes with 5-Hydroxyflavone

“…Thus, 5hydroxyflavone has two adjacent centers that can donate electrons to chelate metal ions and, along with the planarity of the molecule, primuletin can act as a bidentate ligand in complexation reactions with metal ions [20,21]. Metal complexes of 5-hydroxyflavone with magnesium [22], zinc [22], copper [23], iron [23], chromium [24,25], samarium [21], europium [21], gadolinium [21], terbium [21], aluminum [26], gallium [26], and indium [26] have been described in the literature, revealing that through complexation processes, the pharmacological properties of ligands can be modified, with the effects of complexes being in most cases more pronounced than those of ligands alone [21,23,25,[27][28][29][30][31].…”

“…Cyclodextrin-derived nanosponges represent a biocompatible and nontoxic carrier agent solution for preclinical studies, improving the pharmacokinetic and pharmacodynamic profiles of the transported substances [40]. CRLX101 represents a novel nanosubstance Metal complexes of 5-hydroxyflavone with magnesium [22], zinc [22], copper [23], iron [23], chromium [24,25], samarium [21], europium [21], gadolinium [21], terbium [21], aluminum [26], gallium [26], and indium [26] have been described in the literature, revealing that through complexation processes, the pharmacological properties of ligands can be modified, with the effects of complexes being in most cases more pronounced than those of ligands alone [21,23,25,[27][28][29][30][31].…”

A Review on Green Cooling: Exploring the Benefits of Sustainable Energy-Powered District Cooling with Thermal Energy Storage

“…As a result of this heavy load, the conventional DCS is incapable of meeting and sustaining the changes in today's society that are often circumscribed by high energy consumption [16][17][18]. This compelled the integration of TES tanks with VCC systems in DCS plants [19,20], and the integration of renewable energy resources into DCS [2] to boost the efficiency of the process and improve the economic gains of the process. Consequently, the integration of renewable energy resources into DCS has taken center stage in the research in this field in recent decades.…”