Synthesis, spectroscopic characterization, crystal structure and antifungal activity of thiourea derivatives containing a thiazole moiety

Abstract

Abstract:

Synthesis, spectroscopic characterization, crystal structure and pharmacological properties of some novel thiophene-thiourea core derivatives

“…All thioureas (112) were synthesized according to the method of our published papers [33,34] and were obtained in yields ranging from 86 to 95%. The synthesis involves the reaction of thiophene-2-carbonyl chloride with ammonium thiocyanate in dry acetone followed by condensation of the resulting thiophene-2-carbonyl isothiocyanate with an appropriate primary and secondary amine.…”

Synthesis, characterization and antibacterial activity of nickel (II) and copper (II) complexes of N-(alkyl(aryl)carbamothioyl)-4-nitrobenzamide

“…The biological activity of complexes with thiourea derivatives has been successfully screened for various biological processes. On the other hand some thiourea derivatives and their transition metal complexes are also known to exhibit a wide range of biological activities including antiviral, antibacterial, antifungal, anticancer [11][12][13] antitubercular, antithyroidal, herbicidal and insecticidal activities [14] and as agrochemicals [15]. Some acyl thioureas have been found to possess pesticidal activities and promote plant growth [16] while some have been shown to have notable positive effect on the germination of maize seeds as well as on the chlorophyll contents in seedling leaves [17].…”

Metal based drugs: design, synthesis and in-vitro antimicrobial screening of Co(II), Ni(II), Cu(II) and Zn(II) complexes with some new carboxamide derived compounds: crystal structures of N-[ethyl(propan-2-yl)carbamothioyl]thiophene-2-carboxamide and its copper(II) complex

“…Many biologically active thiourea-based (carboxamide) compounds have been reported possessing antibacterial [1][2][3] , antifungal 4,5 , anticancer 6,7 , antiviral 8 , pesticidal 9 , cytotoxic 10 , herbicidal 11 and insecticidal 12 activities. Thiourea derivatives have been effectively used in organocatalysis 13 and as curing agents for epoxy resins.…”