Synthesis, spectroscopic characterization, DNA interaction and antibacterial study of metal complexes of tetraazamacrocyclic Schiff base

Shakir, Mohammad; Khanam, Sadiqa; Firdaus, Farha; Latif, Abdul; Aatif, Mohammad; Al‐Resayes, Saud I.

doi:10.1016/j.saa.2012.03.025

Cited by 18 publications

(6 citation statements)

References 44 publications

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“…The tetraazacyclotetradecane ruthenium complexes synthesized by our group bear 1,4,8,11-tetrazacyclotetradecane (cyclam) or 1,4,8,12-tetrazacyclopentadecane ([15]aneN 4 ) ligands coordinated to ruthenium(II) or (III) compounds (Figure 2). Both species are quite soluble in aqueous solution; the macrocycle (MAC) chelates the metal ion, which in principle offers extra stability to the complex as compared with the open chain ligand [49]. Generally, the ruthenium compound bearing these ligands are isolated as [RuCl 2 (MAC)]Cl.…”

Section: Development Of Ruthenium-derived No Donor Complexesmentioning

confidence: 99%

Ruthenium Complexes as NO Donors for Vascular Relaxation Induction

Lima

Silva

et al. 2014

Molecules

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Nitric oxide (NO) donors are substances that can release NO. Vascular relaxation induction is among the several functions of NO, and the administration of NO donors is a pharmacological alternative to treat hypertension. This review will focus on the physicochemical description of ruthenium-derived NO donor complexes that release NO via reduction and light stimulation. In particular, we will discuss the complexes synthesized by our research group over the last ten years, and we will focus on the vasodilation and arterial pressure control elicited by these complexes. Soluble guanylyl cyclase (sGC) and potassium channels are the main targets of the NO species released from the inorganic compounds. We will consider the importance of the chemical structure of the ruthenium complexes and their vascular effects.

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Section: Development Of Ruthenium-derived No Donor Complexesmentioning

confidence: 99%

Ruthenium Complexes as NO Donors for Vascular Relaxation Induction

Lima

Silva

et al. 2014

Molecules

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“…> g e 2:0023 ð Þ for the complexes support that the unpaired electron occupying the d x 2 À y 2 orbitals with 2 B 1g as the ground state. [33] The EPR results show that the and g ? values are close to 2 ( > g ?…”

Section: Epr Spectroscopymentioning

confidence: 98%

Theoretical, DNA/BSA Binding, Molecular Docking and In Vitro Cytotoxicity Studies of Homoleptic Metal(II) Complexes Derived from 2‐Formylpyridine‐Based Ligands

Jayathuna,

Rajagopal,

Anand

et al. 2024

ChemistrySelect

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A new class of homoleptic metal(II) complexes of general formula [M(L1–4)2]2Cl in which L1=1‐([1,1′‐biphenyl]‐4‐yl)‐N‐(2‐((‐pyridin‐2‐ylmethylene)amino)ethyl)methanimine, L2=1‐([1,1′‐biphenyl]‐4‐yl)‐N‐(2‐((‐pyridin‐2‐ylmethylene)amino)phenyl)methanimine, L3=1‐([1,1′‐biphenyl]‐4‐yl)‐N‐(2‐((‐pyridin‐2‐ylmethylene)amino)‐4‐nitrophenyl)methanimine and L4=4‐(([1,1′‐biphenyl]‐4‐ylmethylene)amino)‐3‐((−pyridin‐2‐ylmethylene)amino)benzophenone, and M=Ni(II) (1–4), Cu(II) (5–8) and Zn(II) (9–12) have been synthesized and characterized. The IR spectra reveal the involvement of azomethine and 2‐formylpyridine ring nitrogen atoms in chelation. The UV‐Vis and EPR spectral studies envisage distorted octahedral geometry around metal(II) ion. All the complexes were stable for 72 h in biologically relevant solutions, and copper(II) complexes were reduced to Cu+ center in the presence of ascorbic acid solution. The binding studies of complexes with calf thymus DNA (CT‐DNA) indicate groove mode of binding, and the complexes 3, 7 and 11 containing the 4‐nitrophenyl substituent exhibit the highest binding affinity than the other complexes. Furthermore, the spectral studies also revealed the interaction of complexes with BSA through static mechanism. In vitro cytotoxicity activity of the complexes was screened against human lung adenocarcinoma (A549) and breast adenocarcinoma (MCF‐7) cancerous, and normal murine fibrosarcoma (L929) cell lines. The molecular docking studies of the homoleptic metal(II) complexes show hydrophobic, π–π, σ–π and hydrogen bonding interactions with EGFR/VEGFR2 kinase receptors.

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“…Furthermore, Schiff bases are also known as chromophores due to the presence of long pi bond conjugated arrangement, which is responsible for the colour [21] . Therefore, they are showed excellent properties such as NLO (nonlinear optical properties), [22] fluorescence [23] and DNA binding [24,25] …”

Section: Introductionmentioning

confidence: 99%

Synthesis, Spectroscopic and Thermal Analysis and Investigation of Dyeing Properties of o‐Hydroxy Schiff Bases and Their Metal Complexes

et al. 2020

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Two series of new Schiff base metal complexes (Cu(II), Ni(II), Co(II), Mn(II), Zn(II)) were synthesized and used to study their fastness and thermal properties. All of the dyes were applied on cotton, polyester and cellulose acetate fabrics as reactive dyes by using temperature and 1 : 20 Flotte ratio. Washing, rubbing and light fastness was investigated by ISO 105‐C06 A2S, TS EN ISO 105‐X12 and ISO 105‐B02 methods, respectively and obtained very well to excellent results. Structures of the metal complex dyes were elucidated by IR, UV‐Vis, 1H‐NMR, 13C‐NMR, mass spectroscopic techniques, magnetic susceptibility measurements, elemental analysis, and thermal analysis. Spectroscopic results indicate that all of the complexes adopt octahedral geometry. Also the results indicate that the complexes are formed by the binding of a metal ion with two Schiff bases by using two >C=N‐ groups, two hydroxyl groups and two aqua ligands. In the present study, for the first time, fabrics were dyed with Schiff bases and metal complexes, and then, their fastness analyses were carried out and were obtained fine results.

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Synthesis, spectroscopic characterization, DNA interaction and antibacterial study of metal complexes of tetraazamacrocyclic Schiff base

Cited by 18 publications

References 44 publications

Ruthenium Complexes as NO Donors for Vascular Relaxation Induction

Ruthenium Complexes as NO Donors for Vascular Relaxation Induction

Theoretical, DNA/BSA Binding, Molecular Docking and In Vitro Cytotoxicity Studies of Homoleptic Metal(II) Complexes Derived from 2‐Formylpyridine‐Based Ligands

Synthesis, Spectroscopic and Thermal Analysis and Investigation of Dyeing Properties of o‐Hydroxy Schiff Bases and Their Metal Complexes

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