Synthesis, spectroscopic characterization, structural studies and antibacterial and antitumor activities of diorganotin complexes with 3-methoxysalicylaldehyde thiosemicarbazone

New organotin(IV) complexes with N(4)-methylthiosemicarbazone derivatives prepared from 2,3-dihydroxybenzaldehyde and 2-hydroxy-5-methylbenzaldehyde: synthesis, characterization, and cytotoxic activity

“…Transition metal complexes of thiosemicarbazone derivatives have been broadly studied for their potential biological applications [16][17][18][19]. Moreover, biological activities of organotin(IV) complexes with thiosemicarbazones have been well established [20][21][22]. A variety of new substituted thiosemicarbazone derivatives are synthesized and explored for their potential biological activities.…”

Synthesis, crystal structures and spectroscopic properties of two new organotin (IV) complexes and their antiproliferative effect against cancerous and non-cancerous cells

“…Discovery of cis-platin by Rosenberg [55] and its new marketing analogues (carboplatin, lobaplatin, oxaliplatin, nedaplatin) have further created interest in metal-based anticancer drugs [1,56]. Tin complexes have been studied in detail as antibacterial agents [9,15,[17][18][19]28] and recently against cancerous cell lines [12,26,57] other than colon cancer. In the current study, complexes 1-2 were tested against three cancerous cell lines (human colon cancer HCT 116, breast cancer MCF-7, leukemia K562) and a non-cancerous cell line (3T3-L1).…”

“…Tin is a non-transition and biocompatible metal [5][6][7] and its complexes have shown significant antibacterial properties [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]. However, tin complexes have been rarely studied against cancer [12,[23][24][25][26][27][28].…”

“…However, tin complexes have been rarely studied against cancer [12,[23][24][25][26][27][28]. The current study is an effort to further explore this area of research.…”

Asynthesis, Crystal Structures and in Vitro Anticancer Studies of New Thiosemicarbazone Derivatives

“…Metal-thiosemicarbazone complexes have been found to have interesting catalytic [3][4][5][6] as well as biological applications 5,[7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] . However, it has been also reported that by suitable structural variations thiosemicarbazone ligands could also become potential anticarcinogenic agents [25][26][27][28][29][30] .…”