Synthesis, Spectroscopic, Coordination, DNA cleavage and Antibacterial activities of Mn(II) complex derived from 1H-Indole-2, 3-dione

Abstract

A new Schiff base ligand was derived from 1H-Indole-2, 3-dione and p-nitroaniline and then it is allowed to react with metal salts to form mononuclear Schiff base metal complex. The synthesized complex was characterized based on elemental analyses, IR, UV, 1 H NMR, molar conductance, and magnetic moment studies. The molar conductance data reveal that the chelates are non electrolytes. An IR spectrum shows that the Schiff bases are coordinated to the metal ions in a manner with NN donor sites of p-nitroaniline. The formation of ligand was also ascertained by 1 H NMR spectra. The electronic spectra show that Mn(II) complex has octahedral geometry. The synthesized ligand, in comparison to their metal complex was screened for their antibacterial activity against bacterial species Staphylococcus aureus, Escherichia coli, Bacillus subtilis and Klebsilla pneumonia. The activity data show that the metal complex is more potent antibacterial than the parent organic ligand against one or more bacterial species. DNA cleavage ability of the synthesized mononuclear Schiff base metal complex was also performed by gel electrophoresis.