Synthesis, spectroscopic, DFT calculations and biological activity studies of ruthenium carbonyl complexes with 2-picolinic acid and a secondary ligand

Synthesis and characterization of Zn(II), Cu(II), Co(II), Ni(II), Cd(II) and Ru(III) ions with a tridentate NNO thiazole derived Schiff base

“…The magnetic moment of the reported complexes was measured and proved paramagnetic properties for cobalt, nickel, copper and ruthenium complexes. These complexes gave no 1 These electronic configurations are in accordance with +2 formal oxidation state of cobalt, nickel and copper in their complexes and +3 formal oxidation state for ruthenium in its complex. According to the present spectroscopic study (IR, 1 H NMR, mass) together with the analytical (elemental analysis, conductivity measurements) and thermodynamic data, the structure of the reported complexes were proposed as shown in Scheme 3 [34,50,51].…”

“…Such complexes have synthetic flexibility, sensitivity and selectivity towards a variety of metal ions. [1][2][3][4][5][6]. Accordingly, this type of complexes has been subjected to be widely investigated [7,8].…”

Synthesis of Sorafenib−Ruthenium Complexes, Investigation of Biological Activities and Applications in Drug Delivery Systems as an Anticancer Agent

“…Finally, the synthesis of ruthenium–sorafenib (RuL 2 S) complexes as a result of the reaction of RuL 2 Cl 2 and sorafenib molecule was carried out according to the method given in the literature. , The complexes were synthesized with yields varying between 18 and 80%. Structures were characterized by 1 H NMR and 13 C NMR spectra.…”

Metallo - Bioactive Compounds as Potential Novel Anticancer Therapy

“…Copper(II) complexes (2), (3), (4) and (5) show bands in the 295-275 and 310-305 nm ranges , these bands are due to intraligand transitions, however, the bands appear in the 495-450, 580-500 and 620-600 nm ranges, are assigned to O→Cu, charge transfer, 2 B 1 → 2 E and 2 B 1 → 2 B 2 transitions, indicating a distorted tetragonal octahedral structure [37,38]. However, manganese(II) complex (9) show bands in the 288-285, 340-300, 440-400, 585-510 and 623-620 nm, the first two bands are within the ligand, however, the other bands are corresponding to 6 A 1g → 4 E g , 6 A 1g → 4 T 2g and 6 A 1g → 4 T 1g transitions which are compatible to an octahedral geometry around the Mn(II) ion [42]. Zinc(II) complexes (6) and (7), mixed complex (8), and silver(I) complex (10) show bands due to intraligand transitions [42].…”

“…Schiff-base compounds containing an imine group are usually formed by the condensation of a primary amines with an active carbonyl or aldehyde group. These compounds are considered as a very important class of organic compounds, which have wide applications in many biological aspects [1].Various Schiff-bases complexes were reported to possess geno-toxicity [2,3],antibacterial [4,5] and antifungal activities [6]. The increasing interest in transition metal complexes containing Schiff-base ligand is derived from their well-established role in biological systems as well as their catalytic and pharmaceutical application [7].…”