Synthesis,Spectroscopic Investigation, Anti-Bacterial and Antioxidant Activites of Some New Azo-Benzofuran Derivatives

Abstract

T hIs Article deals with the stepwise synthesis and spectroscopic characterization of some new azo benzofuran derivatives, started from the diazotization of substituted aniline coupled with 2-hydroxy benzaldehyde. On reacting of the azo of 2-hydroxy benzaldehyde with p-bromo phenacyl bromide, the benzofuran (3a-g) are obtained. The structure of the new benzofuran derivatives have been characterized by using FT-IR, 1h-NMR,13C-NMR and DEPT-135 NMR. The biological activity of some new synthesized compound was obtained by vitro anti oxidant and anti microbial activity with both Staphylococcus aureus and Escherichia coli .The results showed that the new benzofurans have mild anti oxidant activity compared to the standard ascorbic acid.

Novel chalcone-based crown ethers: synthesis, characterization, antioxidant activity, biological evaluations, and wastewater remediation

“…The described product was filtered, washed several times with distilled water and cold ethanol, dried, and then recrystallized in ethanol to obtain white crystals of bis-acetophenones and bis-benzaldehydes with a yield of 81–88%. 21,22 …”

Traditional, One pot Three Component Synthesis and Anti-Bacterial Evaluations of Some New Pyrazoline Derivatives

“…The mixture refluxed with stirring for (30-45min.) and heating (70-80 °C) until the reaction was completed, monitored by TLC, and changed colour [31]. After that, the product was poured into a beaker, condensed for 10 mL and cooled.…”