Synthesis, spectroscopic, thermal and biological activity studies on triazine metal complexes

Badawy, Mohamed A.; Omar, M. M.; Nassar, M.M.I.; Kamel, Amany Hany Mohamed

doi:10.1016/j.saa.2010.08.002

Cited by 15 publications

(8 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, it can be used efficiently to treat the cardiovascular illness (myocardial localized necrosis, thrombosis and stroke), diabetes (insulin-resistant and the related metabolic disorder) [ 1 , 2 , 3 ]. NSAIDs reacted with several-metal ions through amide oxygen and nitrogen of the thyizol groups forming complexes, and the literature data revealed that the biological properties of the complexes are more effective than the starting ligands [ 4 , 5 , 6 ]. The inflammation impact of NSAIDs result from their interaction with the chemical cyclooxygenase (COX), whereas their other natural impacts are COX-independent, counting their impact on tight intersections [ 1 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…Some metal ions perform a substantial role in biological systems’ medications that may alter the distribution of these ions in the blood plasma and other fluids [ 4 ]. The H 2 mel reacted with metal ions forming complexes with octahedral structure and the experimental results refer to meloxicam react as deprotonated bidentate through nitrogen atom of the thiazolyl ring and the amide oxygen with strong intra molecular hydrogen bond between the amide N-H and oxygen atom of enolate [ 5 , 6 ]. Glycine (Gly) ( Scheme 1 b) is one of the proteinogenic amino acids which is used as buffering agents in food production, antioxidants and reacted with metal ions as a bidentate ligand through lone pair of electrons on nitrogen atom of the amide group and ionic charge on oxygen atom of the carboxylic group in presence of some antimicrobial agents such as moxifloxacin, gemifloxacin and lomefloxacin forming complexes [ 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Meloxicam and Study of Their Antimicrobial Effects against Phyto- and Human Pathogens

et al. 2021

View full text Add to dashboard Cite

Recently, the design of new biological metal-ligand complexes has gained a special interest all over the world. In this research, new series of mixed ligand complexes from meloxicam (H2mel) and glycine (Gly) were synthesized. Structures of the compounds were investigated employing elemental analyses, infrared, electronic absorption, 1H NMR, thermal analyses, effective magnetic moment and conductivity. The estimated molar conductivity of the compounds in 1 × 10−3 M DMF solution indicates the non-electrolyte existence of the examined complexes. Additionally, the effective magnetic moment values refer to the complexes found as octahedral molecular geometry. The data of the infrared spectra showed the chelation of H2mel and Gly with metal ions from amide oxygen and nitrogen of the thyizol groups of H2mel and through nitrogen of the amide group and oxygen of the carboxylic group for Gly. Thermal analyses indicated that the new complexes have good thermal stability and initially lose hydration water molecules followed by coordinated water molecules, Gly and H2mel. The kinetic parameters were calculated graphically using Coats–Redfern and Horowitz–Metzeger methods at n = 1 and n ≠ 1. The density functional theory (DFT) calculations were performed at B3LYP levels. The optimized geometry of the ligand and its complexes were obtained based on the optimized structures. The data indicated that the complexes are soft with η value in the range 0.114 to 0.086, while η = 0.140 for free H2mel. The new prepared complexes were investigated as antibacterial and antifungal agents against some phyto- and human pathogens and the minimum inhibitory concentration (MIC) data showed that complex (A) has the lowest MIC for Listeria and E. coli (10.8 µg/mL).

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Meloxicam and Study of Their Antimicrobial Effects against Phyto- and Human Pathogens

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Some data are outlined in table 3. 20 <Table 3 near here> [1,2,4]triazolo [3,4-b][1,3,4]thiadiazines Direct glycosylation of compound 51 with glucopyranosyl bromide 52 in pyridine at room temperature offered a convenient selective synthesis of 2-glycosyl derivative 53 (Scheme 4). 21 <Scheme 4 near here>…”

Section: Thermodynamic Aspectsmentioning

confidence: 99%

Bicyclic 5-6 Systems With One Bridgehead (Ring Junction) Nitrogen Atom: Four Extra Heteroatoms 2:2

Claraz

2022

Comprehensive Heterocyclic Chemistry IV

View full text Add to dashboard Cite

“…Schiff bases are the compounds containing azomethine group (−HC═N−), which play an essential role in the field of coordination chemistry . In recent years, there has been enhanced interest in the development of the chemistry of Schiff base ligands species as they readily form stable complexes with most of the transition metals . From the survey of existing literature, it appears those complexes of Schiff bases have been extensively used as biologically active in the petrochemical industries .…”

Section: Introductionmentioning

confidence: 99%

Study on the nematicidal activity and chemical structure of NO bidentate Schiff base some metal complexes

ElAttar

El-Lattif

Sadeek

2019

J Chinese Chemical Soc

View full text Add to dashboard Cite

A series of Co(II), Cu(II), Y(III), Zr(IV), La(III), and U(VI) complexes derived from 2-(2-hydroxybenzylidinemine)-benzoic acid (L) ligand were synthesized. The mode of bonding of L and the structure of its metal complexes were investigated using different analytical and spectral tools (FT-IR, UV-Vis, 1 H NMR, mass, and XRD). The ligand chelated with the metal ions as a neutral bidentate through oxygen and azomethine nitrogen atoms. All metal complexes adopted octahedral geometry with characteristic color for metal ions. The results of magnetic moment measurements supported paramagnetic for some complexes (Co(II) and Cu(II)) and diamagnetic phenomena for the other complexes. The thermal decomposition of the ligand along with its metal complexes was explained. The molar conductance values of all complexes in (DMF) were found in the range 154.50 to 250.20 S cm 2 mol −1 at room temperature. The activation thermodynamic parameters, such as E*, ΔH*, ΔS* and ΔG*, were calculated from the DTG curves using Coats-Redfern (CR) and Horowitz-Metzeger (HM) methods at n = 1 or n 6 ¼ 1.The nematicidal activity of the synthesized L and their metal complexes was screened. K E Y W O R D S

show abstract

Synthesis, spectroscopic, thermal and biological activity studies on triazine metal complexes

Cited by 15 publications

References 26 publications

Meloxicam and Study of Their Antimicrobial Effects against Phyto- and Human Pathogens

Meloxicam and Study of Their Antimicrobial Effects against Phyto- and Human Pathogens

Bicyclic 5-6 Systems With One Bridgehead (Ring Junction) Nitrogen Atom: Four Extra Heteroatoms 2:2

Study on the nematicidal activity and chemical structure of NO bidentate Schiff base some metal complexes

Contact Info

Product

Resources

About