Synthesis, spectroscopic, thermal, electrical conductivity and antimicrobial interpretations of new VO(II), Zn(II), Pd(II), Au(III) and Pt(IV) complexes with hypertensive atenolol drug

Abstract

Metallo-pharmaceutical interactions were playing a significant role in therapeutic and diagnostic medicine industrials. In literature survey, the studies were proved that when bioorganic molecules were introduced as transition metal chelates they have been increased activities and more therapeutic importance were presented 1,2 ABSTRACTNew complexes of VO(II), Zn(II), Pd(II), Au(III) and Pt(IV) with atenolol (ATN) hypertensive drug ligand were synthesized and characterized by elemental analysis, conductometry, magnetic susceptibility, UV-Vis, IR, ESR, 1 H-NMR spectroscopy, X-ray diffraction analysis of powdered samples, scanning electron microscopy (SEM), and thermal analysis. The IR spectral data suggested that the ATN ligand behaves as a monobasic bidentate ligand towards the central metal ion with nitrogen atom of -NH secondary amine and the oxygen atom of -OH group after deprotonated. From the microanalytical data, the stoichiometry of the complexes 1:2 (metal: ligand) was found. The ligand and their metal complexes were screened for antibacterial activity against (Escherichia coli, and Staphylococcus aureus) and fungicidal activity against (Aspergillus flavus and Candida albicans). The Electrical conductivities of ATN and its metal complexes were also measured with DC electrical conductivity in the temperature range from room to 483 K.

Synthesis, Spectral and Electrochemical Properties and DFT Studies of Two Complexes of Ruthenium with Bis-2,3-(2-Pyridyl)Pyrazine and 4-Picoline

“…There has been considerable current interest in the synthesis of platinum metal complexes [1][2][3][4][5][6][7][8][9][10][11][12][13] having fascinating catalytic 6,7,12, biological 11,12 and photophysical/photochemical 12 properties. The coordination environment around the central metal often influences these properties of the complexes.…”