Synthesis, spectroscopic, thermal, voltammetric studies and biological activity of crystalline complexes of pyridine-2,6-dicarboxylic acid and 8-hydroxyquinoline

8-Hydroxyquinolines: a review of their metal chelating properties and medicinal applications

“…It is widely known that mixed ligand metal complexes can commonly occur in biological fluids from various bioactive ligands with metal ions 154. Interest in the area of metal complexation has steadily increased.…”

Calculation of Solubility of Oxyquinolinates

“…Then from Equation (A1) we have Equation (20). Note that 2 0 q d = − > and 3 0 p c = − > , at any pH-value, see Equation (19) and comments for Equations (16) and (17).…”

“…In this context, the oxine derivatives have been reported as potent antioxidants [13]- [16], which arise from their chelating ability. It is widely known that mixed ligand metal complexes can commonly occur in biological fluids from various bioactive ligands with metal ions [17]. Ability to chelate and lipophilicity have been regarded as essential to the action of oxine.…”

The strongin vitroandvivocytotoxicity of three new cobalt(ii) complexes with 8-methoxyquinoline

“…In particular, a series of cobalt( iii ) complexes of 8-hydroxyquinoline and its derivatives has been designed, showing remarkable antitumor activity. 27 Nonetheless, in spite of cobalt( ii ) and copper( ii ) complexes bearing 8-methoxyquinoline (MQL) having been reported, 28 their apoptosis mechanisms remain unknown as of yet. Considering the recent reporting of a Pt( ii ) coordination compound bearing 8-hydroxy-2-methylquinoline, whose activity as a tumor inhibitor for the treatment of BEL-7404 tumor cells (IC 50 = 7.29 ± 0.23 μM) was demonstrated, 29 the anti-proliferative activity of cobalt( ii ) complexes could be expected to be enhanced upon introducing a methyl group.…”