Synthesis, Spectroscopic, Thermodynamic and Biological Activity Studies of Schiff base and Metal Complexes derived from 2-[(1H-Pyrrol-2-ylimino methyl)]- 5-(2-hydoxy-phenyl)-[1,3,4-thiadiazol]

Abstract

New metal complexes of type M2(HL)2.4H2O[(M = Co(II), Ni (II) and Cu (II)] were prepared using the ligand (HL) =2-[(1H-Pyrrol-2-ylimino methyl)]-5-(2-hydoxy-phenyl)-[1,3,4-thiadiazol]. The Schiff bases were was condensed from [1H-Pyrrole-2-carbaldehyde] with [2-amino-5-(2-hydroxy-phenyl-1,3,4-thiadiazole] in alcoholic medium. The prepared complexes were characterized by FTIR, UV-vis, 1H-NMR and mass spectra as well as magnetic susceptibility measurements, thermal analysis. The activation thermodynamic parameters, such as ΔE * , ΔH * , ΔS * and ΔG * are calculated from the TGA curve using Coats-Red fern method. From the spectral measurements, structures for the complexes were proposed. Preliminary in vitro tests for antimicrobial activity show that all prepared compounds display good activity to Staphylococcus aureus, Escherishia coli, Pseudononas aeroginosa and Cndida albicans.

Preparation and Characterization of New Tetra-Dentate N₂O₂ Schiff Base with Some of Metal Ions Complexes

“…For all complexes, a new beam appeared in the range of 586-590 cm -1 due to the vibrations of the group stretch (M-O) [16] and showed a stretching of the group (M-N) of the prepared complexes in the bounded region between 458 and 495 cm -1 . This confirms the metal's association via the N atom [17]. All the infrared spectrum values for the complexes are shown in Table 2.…”