Synthesis, Spectroscopy, Semi‐empirical and Biological Activities of Organotin(IV) Complexes with o‐Isopropyl Carbonodithioic Acid

Abstract

New organotin(IV) complexes have been synthesized by treating potassium o‐isopropyl carbonodithioate with R2SnCl2/R3SnCl in 1 : 2/1 : 1 M/L ratio. All complexes have been characterized by IR and NMR (1H, 13C) spectroscopy. IR results shows that ligand acts as bidentate which is also confirmed by semi‐empirical study. NMR data reveals four coordinated geometry in solution. Computed positive heat of formation shows that complex 5 is thermodynamically unstable. UV/visible spectroscopy was used to assess the mode of interaction and binding of the complexes with DNA which shows that complex 5 exhibits higher binding constant as compared to complex 3. In protein kinase inhibition assay, compound 3 was found most active, while other biological activities shows that triorganotin(IV) complexes are biologically more active as compared to diorganotin(IV) complexes.

Synthesis and Characterization of Novel Diorganotin(IV) Complexes Derived from N-Methyl-phenethyl Dithiocarbamate and Bis(2-ethoxyethyl) Dithiocarbamate

“…This bond plays one of the major roles in the activity of the whole compound [3]. Organotin derivatives have gotten a lot of attention in the previous decades due to its numerous biological activities ranging from antibacterial and antifungal properties [4][5][6][7][8] to antiproliferative and anticancer properties [9][10][11][12][13][14] as well as larvicidal properties [15]. Most organotin(IV) compounds are found to be very toxic, even at low concentrations [1].…”

Effect of fluorinated/non‐fluorinated β‐diketones and side‐chain branching of N‐protected amino acids on the antibacterial potential of new heptacoordinated monobutyltin(IV) complexes

“…The biological activity and technological properties may be correlated with the structural features of organotin(IV) complexes. The structural features of organotin(IV) complexes may be altered by assembly of various potential organic ligands on the central tin atom . The biological activity of organotin(IV) complexes may be influenced by the nature and number of donor atoms of organic ligands, presence or absence of fluorine, coordination number of tin and geometry of the resulting complexes.…”