Synthesis, spectroscopy, thermal and biological aspect of novel six‐coordinated dimeric iron(III) mixed‐ligand complexes

Abstract

The mixed-ligand complexes of iron(III) with 1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydroquinoline-3-carboxylic acid and various neutral bidentate Schiff base ligands were prepared. The structure of mixed-ligand complexes was investigated using spectral, physicochemical and elemental analyses. Biocidal activity was determined using agar plate technique against Staphylococcus aureus, Bacillus subtilis, Bacillus cereus, Salmonella typhi, Escherichia coli and Serratia marcescens. The result showed a significant increase in a biocidal activity compared with parent ligands, metal salts and standard drugs (ofloxacin, levofloxacin). DNA binding and cleavage studies were carried out using absorption titration and gel electrophoresis techniques, respectively. The binding constant of Fe(III) complexes was obtained in the range 2.5-4.0 × 10 4 M −1 . The DNA binding and cleavage efficacy were raised in mixed-ligand complexes as compared with parental ligands and metal salts.

Synthesis, spectral investigation and biological interphase of drug‐based cytotoxic square pyramidal coordination compounds

“…Sigman and co‐workers developed the first chemical nuclease [Cu(phen) 2 ] that effectively cleaves B‐DNA in the minor groove in the presence of a reducing agent and also exhibits antiviral activity, which inhibits proviral DNA synthesis . In continuation of earlier work, our experimental studies provide information regarding nuclease behaviour of synthesized metal complexes. Various biological parameters (DNA interaction behaviour, cytotoxic assessment) were evaluated for known efficient nuclease behaviour.…”

Structure Studies of the Prepared Novel Hydrazone Schiff’s Base Complexes Using Spectroscopic, Thermal Analyses and Their Biological Activities

“…The molar magnetic susceptibility was measured on powdered samples using Faraday method. The diamagnetic corrections were made by Pascal's constant and Hg[Co(SCN) 4 ] was used as a calibrant. The magnetic data for the background of the sample holder were corrected.…”

“…The synthesis of macrocyclic complexes have great potential applications in fundamental and applied sciences [3,4,5]; biochemistry, material science, catalysis, encapsulation, activation, transport and separation phenomena, hydrometallurgy, etc. and importance in the area of inorganic chemistry [6,7].…”

Chemistry of 3-carbonyl-2-methyl-4-oxo-4H-1-benzopyrans

“…An Indian group [102][103][104] have prepared novel six coordinated dimeric Fe(III) as well as five coordinated dimeric Fe(II) and Cu(II) complexes with 3-acetyl-7-ethoxy-2-methylchromone 254 as one ligand (L) along with two other ligands, namely 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 255 and piperazine 256 (abbreviated respectively as cip 104 having respectively the octahedral, distorted square pyramidal and square pyramidal geometry. Each metal in these complexes is coordinated to the deprotonated carboxylate oxygen and pyridine oxygen of cip, two carbonyl oxygens of chromone ligand L and one nitrogen of piperazine.…”