Synthesis, Stereochemistry, and Antimicrobial Activity of 2,6‐Diaryl‐3‐(arylthio)piperidin‐4‐ones.

Abstract

Pyridine derivatives R 0380Synthesis, Stereochemistry, and Antimicrobial Activity of 2,6-Diaryl-3-(arylthio)piperidin-4-ones. -A series of novel 3-arylthiopiperidinone derivatives (20 examples in all) is synthesized via multicomponent reactions and evaluated for antibacterial and antifungal effects. Derivatives (IIIc), (Vb) and (VIIb), show almost the same antibacterial activity as streptomycin and antifungal activity comparable to nystatin.-(SRINIVASAN, M.; PERUMAL*, S.; SELVARAJ, S.; Chem.

Synthesis of Novel Pyridopyridazin-3(2H)-one Derivatives and Evaluation of Their Cytotoxic Activity against MCF-7 Cells

“…Therefore, it was important to determine the preferred types of chair or boat conformations of 1a-f, 2a-f, and 3a-f. The conformational assignments were investigated using 13 C NMR (chemical shifts) and 1 H NMR (vicinal coupling constants) spectra [25][26][27][28]. The dihedral angles derived from the vicinal coupling constant values obtained from the 1 H NMR spectrum of 3b suggested a chair conformation to the piperidine ring and a distorted/half-chair conformation to the pyridazine ring.…”

A1,3‐strain mediated epimerization of 2e,3e,5e,6e‐tetraarylpiperidin‐4‐one oximes

“…All the piperidones were prepared by a literature method. 10 The 1 H and 13 C NMR spectra of the tri-and tetraarylpiperidin-4-one oximes were measured in CDCl 3 at 300 and 75 MHz, respectively, using a Bruker Avance NMR spectrometer, with the chemical shifts referenced to tetramethylsilane.…”

A Facile L‐Proline Catalyzed One‐Pot Synthesis of Xanthene and Acridine Based Quinolones via Knoevenagel Condensation Reaction

“…Due to the fact that this can act as a ligand as well as a catalyst in many asymmetric transformations including aldol reaction, additions to imines and nitroalkenes, Mannich reaction, conjugate addition, Michael addition reactions, etc. L‐proline is preferred as catalyst over other amino acids because it is the only secondary proteinogenic amino acid possessing special rigidity that could control the stereochemistry through the formation of imine/enamine intermediate …”