Synthesis, structural and spectral characteristics of novel n,π-chelate complexes of Pd(II) and Pt(II) with N-allylthioureas and their influence on the growth of spheroids cells MCF-7 and GGT activity

Iodide n,π-chelate complexes of platinum(II) based on N-allyl substituted thioureas and their effect on the activity of hepatobiliary system enzymes in comparison with chloride analogs

“…5, Table 1) shows a significant downfield shift of the proton signals of NH groups (Δδ H = +1.37/1.34 ppm) and the upfield shift of the proton signals of allylic fragment (=C 8 H trans , = C 8 H cis , -C 7 H= by Δδ H = -(0.5-0.85/-0.42-0.68) ppm), which are part of the six-membered metallocycle with formation of a π-coordination bond (C 8 = C 7 )→Pt (Scheme 1). These signal shifts are analogous to the chloride counterparts of these complexes synthesized by us earlier [16,18,19]. However, unlike chloride complexes, the values of these shifts are smaller, which is due to the lower electronegativity of iodide anions compared to chloride ones.…”

“…As in our previous works [16][17][18][19] a feature of the structure of both complexes is coordination of thioureas HL 1 and HL 2 in a bidentate-chelate manner by the atoms of the S,C-allylthiourea group, and the cis-position of iodide anions in the coordination sphere of the metal (Scheme 1).…”

“…These absorption bands undergo both bathochromic and hypsochromic shifts of +20/21 and - (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22) nm relative to their chloride counterparts (green curves in Fig. 2) studied in our previous publications [17,19].…”

“…Promising ligands for the development of new potential drugs are thiourea derivatives, which, having high antitumor activity [12], are able to coordinate many metal ions as N,S donor agents [13][14][15]. In previous studies, we found that a number of π-coordination complexes of Pt(II) and Pd(II) with N-allylthiourea derivatives showed a high affinity to DNA with cytostatic and proapoptotic effects which was superior to that of cisplatin [16][17][18][19]. As a "carrier ligand" providing transport of these complexes to their target, we used the allylthiourea derivatives and the role of the leaving groups was performed by chlorine atoms.…”

“…N-Allylmorpholine-4-carbothioamide (HL 1 ) and 3-allyl-1,1-diethylthiourea (HL 2 ) were obtained as a white solid by the methods described in our previous works [16,18,19]. HL All the complexes were synthesized according to the following general methodic: A portion of K 2 [PtCl 4 ] (103.7 mg, 0.25 mmol) was dissolved in 1 ml of distilled water and 0.5 ml of 2N HCl was added.…”