Synthesis, structural, biological andin silicostudies of new 5-arylidene-4-thiazolidinone derivatives as possible anticancer, antimicrobial and antitubercular agents

Abstract

Thiazolidinone–sulfonamide hybrids emerged as promising anticancer and antitubercular agents, and their anticancer activity was confirmed by docking studies.

Dinuclear oxidovanadium complexes with dihydrazone ligands derived from diethyl 2,6-dimethylpyridine-3,5-dicarboxylate obtained from Hantzsch reaction; crystal structure and catalytic activity

“…In the spectrum of (NH 4 ) 2 [(VO 2 ) 2 L 1 ]·(CH 3 OH) 2 (H 2 O) 0.33 ( 1 ), the broad bands at 3197 cm −1 are related to the NH group of the ammonium cation and the broadband at 3450 cm −1 can be attributed to the OH groups of methanol and water molecules in the structure of 1 . 27 The strong band at 1598 cm −1 is devoted to the CN group 28 and the bands observed at 999, 688 and 457 cm −1 are attributed to the VO, V–N and V–O groups, 29 respectively. In the spectrum of (NH 4 ) 2 [(VO 2 ) 2 L 2 ]·(H 2 O) ( 2 ), the strong band at 1609 cm −1 is assigned to the CN and the observed bands at 3190 and 3485 cm −1 can be respectively devoted to the NH group of ammonium and water molecules in the structure of 2 .…”

Experimental and Theoretical Approach for the Corrosion Deceleration of Mild Steel in Hydrochloric Acid Medium by Two Sulfonamide Derivatives

“…PQS and MQS efficacy of inhibition at a low concentration of 40 ppm preeminently compared to other reported sulfonamide inhibitors [8] which are depicted in Table 3. PQS possesses higher efficacy than MQS ascribing to the prevalent electron releasing methyl group [39] on the pyrimidine ring of MQS resulting in moderate destabilization due to inter‐electronic repulsions that decline its efficiency marginally.…”

“…Kumar, et al . on quinazoline derivatives reports the positive value of $${{\Delta H}^{\#}{\rm \ }}$$ implies dissolution of metal to be an endothermic process and rise in $${{\Delta S}^{\#}}$$ implies ascent in entropy of solution and descent in entropy of MS [39] . The $${{\Delta H}^{\#}}$$ values are higher than the blank for PQS and MQS, correspondingly $${{\Delta S}^{\#}}$$ values are higher and negative which imputes the formation of an activated complex during the adsorption of inhibitors [45] …”

4-Thiazolidinone-Bearing Hybrid Molecules in Anticancer Drug Design

“…Multifunctional sulfanilamide-bearing hybrids were developed and tested against HepG2 and MDA-MB-231 cancer cell lines by Sunil Kumar et al [ 23 ]. Among the tested hybrids, compound 10 ( Figure 4 ) was identified as potent against the MBA-MB-231 cell line and showed the highest cytotoxic activity, with an IC 50 value of 17.45 µM, which was higher than in the case of the standard drug cisplatin.…”