Synthesis, structural characterization and antimicrobial activities of 12 zinc(II) complexes with four thiosemicarbazone and two semicarbazone ligands

Kasuga, Noriko Chikaraishi; Sekino, Kiyoshi; Ishikawa, Motoki; Honda, A.; Yokoyama, Masaki; Nakano, Saori; Shimada, Nobuhiro; Koumo, Chisa; Nomiya, Kenji

doi:10.1016/s0162-0134(03)00156-9

Cited by 235 publications

(125 citation statements)

References 28 publications

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“…terminal Zn-Cl bonds. [17] The Zn-S and C-S distances [2.369 and 1.711 Å, respectively] are similar to those found in other complexes with thiocarbonyl sulfur atoms.…”

Section: Synthesis and Structure Of The Complex [Zn(hta3t-et) 2 CL 2 ]supporting

confidence: 77%

Synthesis, Characterization and X‐ray Structures of [α‐Diphenylethanedione bis(4‐ethylthiosemicarbazonato)]palladium(II) and 1,2,4‐Triazine‐3‐thione–Zinc(II) Complexes Obtained by Metal‐Induced Cyclization

2007

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“…terminal Zn-Cl bonds. [17] The Zn-S and C-S distances [2.369 and 1.711 Å, respectively] are similar to those found in other complexes with thiocarbonyl sulfur atoms.…”

Section: Synthesis and Structure Of The Complex [Zn(hta3t-et) 2 CL 2 ]supporting

confidence: 77%

Synthesis, Characterization and X‐ray Structures of [α‐Diphenylethanedione bis(4‐ethylthiosemicarbazonato)]palladium(II) and 1,2,4‐Triazine‐3‐thione–Zinc(II) Complexes Obtained by Metal‐Induced Cyclization

2007

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“…Biological activities of metal complexes differ from those of either ligands or the metal ions, and increase and/or decreased biological activities are reported for several transition metal complexes. Thiosemicarbazone are versatile compounds; two structural isomers (E-, Zform) are possible and they can co-ordinate to the metal either as a neutral ligand or as a deprotonated ligand through the NS atoms (West et al, 1996;Kasuga et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Synthesis and biological activity of acetylacetone thiosemicarbazone and their metallic complexes

Kumar¹,

Kumar

2013

Int Curr Pharm J

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In present work, Ligand acetylacetone thiosemicarbazone and their 11 complexes of the type ML2X2, ML2X, where M = Cu(II), Cd(II), Co(II), Zn(II), Hg(II); L = acetylacetone thiosemicarbazone; X = Cl, NO3 or CH3COO; X = SO4 have been synthesized and characterized with the help of molar conductance, magnetic susceptibility measurements, infra-red and ultra-violet spectroscopy. The spectral data revealed that the thiosemicarbazone act as bidentate ligand, making use of thionic sulphur and the azomethine nitrogen atom for co-ordination to the central metal atom. All the compounds have been screened for their antibacterial activity against Gram positive bacteria Staphylococcus aureus, Staphylococcus epidermidis and Gram negative bacteria Escherichia coli and Pseudomonas aeruginosa. Some of complexes exhibited appreciable activity.DOI: http://dx.doi.org/10.3329/icpj.v2i4.14057 International Current Pharmaceutical Journal, March 2013, 2(4): 88-91

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“…Many heterocyclic thiosemicarbazone derivatives and their platinum and palladium complexes have a wide range of pharmacological activities, such as antituberculosis [28], antibacterial [29], antitumor [30], antiprotozoal [31], antimalarial [32], antimicrobial [33], antiviral [34], antifungal [35], anticonvulsant [36] and anti-trypanosomal [37] activities. In our present work, the synthesis and characterization of thiosemicarbazones derived from 5-substitutedthiophene-2-carboxaldehydes and their platinum(II) and palladium(II) complexes are reported.…”

Section: Introductionmentioning

confidence: 99%

Novel platinum(II) and palladium(II) complexes of thiosemicarbazones derived from 5-substitutedthiophene-2-carboxaldehydes and their antiviral and cytotoxic activities

Karaküçük‐İyidoğan

Tasdemir

Oruç‐Emre

et al. 2011

European Journal of Medicinal Chemistry

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a b s t r a c tA series of thiosemicarbazones and their platinum(II) and palladium(II) complexes have been synthesized. The chemical structures of ligands and their complexes were characterized by UVeVis, IR, 1 H NMR, 13 C NMR, MS spectra, elemental analysis and TGA. The antiviral and cytotoxic activities of all compounds have been tested. Results of broad antiviral evaluation showed that none of the compounds evaluated endowed with anti-DNA or -RNA virus activity at subtoxic concentrations except for the palladium complex 1b. This compound exhibited slightly selective inhibition against cytomegalovirus. The platinum complex 4a exhibited the best cytostatic activities against human cervix carcinoma. Ligands 2, 4 and 5 showed cytostatic potential. The palladium complexes were in general less cytostatic than the corresponding platinum complexes or unliganded congeners.

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Synthesis, structural characterization and antimicrobial activities of 12 zinc(II) complexes with four thiosemicarbazone and two semicarbazone ligands

Cited by 235 publications

References 28 publications

Synthesis, Characterization and X‐ray Structures of [α‐Diphenylethanedione bis(4‐ethylthiosemicarbazonato)]palladium(II) and 1,2,4‐Triazine‐3‐thione–Zinc(II) Complexes Obtained by Metal‐Induced Cyclization

Synthesis, Characterization and X‐ray Structures of [α‐Diphenylethanedione bis(4‐ethylthiosemicarbazonato)]palladium(II) and 1,2,4‐Triazine‐3‐thione–Zinc(II) Complexes Obtained by Metal‐Induced Cyclization

Synthesis and biological activity of acetylacetone thiosemicarbazone and their metallic complexes

Novel platinum(II) and palladium(II) complexes of thiosemicarbazones derived from 5-substitutedthiophene-2-carboxaldehydes and their antiviral and cytotoxic activities

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