Synthesis, structural characterization and antiproliferative activity on MCF-7 and A549 tumor cell lines of [Cu(N-N)(β3-aminoacidate)]NO3 complexes (Casiopeínas®)

Valdéz-Camacho, Jonathan Román; Pérez-Salgado, Yaquelinne; Espinoza-Guillén, Adrián; Gómez‐Vidales, Virginia; Tavira-Montalván, Carlos Alberto; Meneses‐Acosta, Angélica; Leyva, Marco A.; Vázquez-Ríos, María G.; Juaristi, Eusebio; Höpfl, Herbert; Ruíz-Azuara, Lena; Escalante, Jaime

doi:10.1016/j.ica.2020.119542

Cited by 14 publications

(4 citation statements)

References 58 publications

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“…The geometry found for 1 and 2 was similar to recently reported Casiopeínas®-like complexes presenting amino acids and 2-hydroxybenzophenones crystal structures. 28,29 The [Cu(N–N)(β 3 -aminoacidate)]NO 3 complexes 29 and the complex [Cu(phen)(2H4MeBz)(ClO 4 )] 28 presented two bidentate ligands, N-heterocyclic and an O,O-donor to stabilize the copper( ii ) center, similar to those reported here.…”

Section: Resultssupporting

confidence: 78%

Exploring the BSA- and DNA-binding, cytotoxicity, and cell cycle evaluation of ternary copper(ii)/diimine complexes with N,N-dibenzyl-N′-benzoylthiourea as promising metallodrug candidates

Gonçalves,

Teixeira,

Bezerra

et al. 2024

Dalton Trans.

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Section: Resultssupporting

confidence: 78%

Exploring the BSA- and DNA-binding, cytotoxicity, and cell cycle evaluation of ternary copper(ii)/diimine complexes with N,N-dibenzyl-N′-benzoylthiourea as promising metallodrug candidates

Gonçalves,

Teixeira,

Bezerra

et al. 2024

Dalton Trans.

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“…Además, los diferentes tipos de ligantes que los acompañan (tales como NHC, heterociclos, organoarsénicos, drogas aprobadas clínicamente o incluso estructuras supramoleculares) también sirven como variable de modulación. Entre los compuestos que se han estudiado, los más sobresalientes son los de Ru, Os, Ir, Fe (familias de compuestos organometálicos derivados del ferroceno y familias de compuestos de coordinación con ligantes quelantes), Cu (las famosas casiopeínas desarrolladas en nuestro país) (Espinal-Enríquez et al, 2016;Valdez-Camacho et al, 2020), Au, Ti, V e incluso compuestos heterometálicos. Algunos de estos compuestos han alcanzado pruebas en fase clínica tales como los de Ru (KP1019), Au y Cu (Fig.…”

Section: Aplicaciones De Los Compuestos Organometálicos Y De Coordina...unclassified

Compuestos organometálicos y de coordinación: Más que sólo una buena relación de metales de transición y moléculas orgánicas

Osorio-Yáñez

Morales‐Morales

2021

tecnociencia

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La química organometálica y de coordinación ha sido la inspiración de muchos científicos alrededor del mundo durante décadas debido a que las aplicaciones en las que los compuestos organometálicos y de coordinación han encontrado cabida, son diversos y estimulantes, tal es el caso de la catálisis, en la síntesis de metalodrogas o en la activación de moléculas pequeñas como CO2, H2, CH4 y N2. La síntesis de estos compuestos per se es interesante y el estudio de su reactividad ha permitido el desarrollo de procesos más eficientes y selectivos que permiten que nuestra vida cotidiana sea, no solamente más cómoda y duradera, sino más amigable con la naturaleza. En este artículo de revisión se presenta un panorama general de los avances que se han tenido a partir de la síntesis de los primeros compuestos inorgánicos hasta nuestros días y que han permitido el nacimiento de una plétora de subáreas que siguen siendo motivación para nosotros y para muchos grupos de investigación en el mundo. De igual manera se presentan las perspectivas a las que estas investigaciones apuntan a futuro con la finalidad de motivar al lector(a) a que siga por el estimulante camino del estudio de la química organometálica y de coordinación. DOI: https://doi.org/10.54167/tecnociencia.v15i3.855

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“…4,5 Copper (II) complexes, may be an alternative on platinum-based complexes, are remarkable because they show interesting biological properties. [6][7][8][9] Schiff bases and their metal complexes derived from amino acids and salicylaldehyde derivatives have been the topic of research for years because of their biological activities. 10,11 Salicylaldehyde and derivatives reacts with the amino acid to form versatile multidentate Schiff base ligands that could activate promising biological function.…”

Section: Introductionmentioning

confidence: 99%

“…The strategy for obtaining new active compounds may be to investigate their interactions with biomolecules, to try to increase the specificity and to reduce the side effects of the drug 4,5 . Copper (II) complexes, may be an alternative on platinum‐based complexes, are remarkable because they show interesting biological properties 6–9 . Schiff bases and their metal complexes derived from amino acids and salicylaldehyde derivatives have been the topic of research for years because of their biological activities 10,11 .…”

Section: Introductionmentioning

confidence: 99%

New copper (II) complexes bearing tryptophan‐based Schiff bases and 2,2′‐bipyridine: Crystal structures, DNA/BSA interactions and antiproliferative activities

Özbağcı,

Gültekin,

Aydın

et al. 2024

Applied Organom Chemis

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Abstract[Cu(5‐ClSal‐Trp)(bpy)]·CH3OH (1) and [Cu(3,5‐ClSal‐Trp)(bpy)]·H2O (2) (5‐ClSal‐Trp: Schiff base derived from 5‐chlorosalicylaldehyde and tryptophan, 3,5‐ClSal‐Trp: Schiff base derived from 3,5‐dichlorosalicylaldehyde and tryptophan, bpy: 2,2′‐bipyridine) have been synthesized and analyzed by CHN analysis, FTIR, electronic absorption spectroscopy, ESI‐MS and XRD techniques. Interaction of the complexes with biomolecules {calf thymus DNA (CT‐DNA) and bovine serum albumin (BSA)} has been researched by fluorescence and electronic absorption spectroscopy. The results show that the complexes can bind via a moderate intercalation binding mode. According to the results obtained with both methods, the logKb and logKSV values of the complexes were found to be very close to each other. BSA quenching mechanism was found to be static. The results showed that the interaction between the complexes and BSA is driven by the hydrogen bond and van der Waals interaction. Additionally, the r values of the complexes (the complex 1 = 0.59 nm and the complex 2 = 0.53 nm) calculated from FRET theory suggested that the distance between the complexes (acceptor) and BSA (donor) is quite close. The complexes exhibited free radical scavenging activity compared to the standard antioxidant β‐carotene and catechin. Antiproliferative efficiency of the complexes on both breast cancer cells (MCF‐7 and MDA‐MB‐231) were also researched using the Sulforhodamine B (SRB) viability assay. It was found that the complex 1 (IC50 = 10.99 μM) exhibited higher cytotoxicity than cisplatin (IC50 = 15.6 μM) against MDA‐MB‐231 cell line. Additionally, intracellular reactive oxygen species (ROS) formation was determined by dihydroethidium (DHE) fluorescent staining. N‐acetylcysteine (NAC) was used as an efficient reactive oxygen species (ROS) scavenger. It was observed that newly synthesized Cu (II) complexes exhibited anti‐growth potential in human breast cancer cells. Additionally, it was determined that the complexes induced reactive oxygen species (ROS) formation in cells in a dose‐dependent manner.

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Synthesis, structural characterization and antiproliferative activity on MCF-7 and A549 tumor cell lines of [Cu(N-N)(β3-aminoacidate)]NO3 complexes (Casiopeínas®)

Cited by 14 publications

References 58 publications

Exploring the BSA- and DNA-binding, cytotoxicity, and cell cycle evaluation of ternary copper(ii)/diimine complexes with N,N-dibenzyl-N′-benzoylthiourea as promising metallodrug candidates

Exploring the BSA- and DNA-binding, cytotoxicity, and cell cycle evaluation of ternary copper(ii)/diimine complexes with N,N-dibenzyl-N′-benzoylthiourea as promising metallodrug candidates

Compuestos organometálicos y de coordinación: Más que sólo una buena relación de metales de transición y moléculas orgánicas

New copper (II) complexes bearing tryptophan‐based Schiff bases and 2,2′‐bipyridine: Crystal structures, DNA/BSA interactions and antiproliferative activities

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