Synthesis, structural characterization and antitumoral activity of (NH4)4Li2V10O28.10H2O compound

Ksiksi, Regaya; Abdelkafi-Koubaa, Zaineb; Mlayah-Bellalouna, Saoussen; Aissaoui, D.; Marrakchi, Naziha; Srairi-Abid, Najet; Zid, Mohamed Faouzi; Graia, Mohsen

doi:10.1016/j.molstruc.2020.129492

Cited by 15 publications

(13 citation statements)

References 18 publications

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“…Their presence may enhance the lipophilic effect of this compound, which increases its penetration through the lipid bilayer of the cell membrane, thus showing higher inhibitory activity than the second compound. After that, a few more articles based on decavanadates compounds with potential antitumor activity have been published up to the present [29,53,[59][60][61].…”

Section: Discussionmentioning

confidence: 99%

2-Aminopyrimidinium Decavanadate: Experimental and Theoretical Characterization, Molecular Docking, and Potential Antineoplastic Activity

et al. 2021

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The interest in decavanadate anions has increased in recent decades, since these clusters show interesting applications as varied as sensors, batteries, catalysts, or new drugs in medicine. Due to the capacity of the interaction of decavanadate with a variety of biological molecules because of its high negative charge and oxygen-rich surface, this cluster is being widely studied both in vitro and in vivo as a treatment for several global health problems such as diabetes mellitus, cancer, and Alzheimer’s disease. Here, we report a new decavanadate compound with organic molecules synthesized in an aqueous solution and structurally characterized by elemental analysis, infrared spectroscopy, thermogravimetric analysis, and single-crystal X-ray diffraction. The decavanadate anion was combined with 2-aminopyrimidine to form the compound [2-ampymH]6[V10O28]·5H2O (1). In the crystal lattice, organic molecules are stacked by π–π interactions, with a centroid-to-centroid distance similar to that shown in DNA or RNA molecules. Furthermore, computational DFT calculations of Compound 1 corroborate the hydrogen bond interaction between pyrimidine molecules and decavanadate anions, as well as the π–π stacking interactions between the central pyrimidine molecules. Finally, docking studies with test RNA molecules indicate that they could serve as other potential targets for the anticancer activity of decavanadate anion.

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Section: Discussionmentioning

confidence: 99%

2-Aminopyrimidinium Decavanadate: Experimental and Theoretical Characterization, Molecular Docking, and Potential Antineoplastic Activity

et al. 2021

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“…In 2010, Li et al developed two decavanadates with organic ligands that inhibited human lung development (A549) and murine leukemia (Li et al, 2010). A slew of other papers on decavanadate compounds with anticancer potential have appeared (Kioseoglou et al, 2013;Cheng et al, 2018;Gu et al, 2020;Louati et al, 2021;Ksiksi et al, 2021a;2021b). On the other hand, studies on Tris(2-pyridylmethyl)amine as an osteosarcoma (OS) antitumor agent is linked to higher miRNAs and proteins involved in several signaling pathways.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Anticancer properties of vanadium(V) anionic compounds have been discovered ( Cheng et al, 2018 ; Silva-Nolasco et al, 2020 ). Mg(H 2 O) 6 (C 4 N 2 H7) 4 V 10 O 28 •4H 2 O and (C 7 H 10 N) 4 [H 2 V 10 O 28 ]•2H 2 O were recently shown to have dose-dependent antiproliferative activity against human cancer cells U87, IGR39, and MDA-MB-231 ( Ksiksi et al, 2021 ; Louati et al, 2021 ). The in vitro encapsulation of V(IV)-curcumin-bipyridine (VCur) with magnetic cationic liposomes improves the compound’s stability and solubility in physiological media ( Halevas et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

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Tris(2-Pyridylmethylamine)V(O)2 Complexes as Counter Ions of Diprotonated Decavanadate Anion: Potential Antineoplastic Activity

et al. 2022

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The synthesis and theoretical-experimental characterization of a novel diprotanated decavanadate is presented here due to our search for novel anticancer metallodrugs. Tris(2-pyridylmethyl)amine (TPMA), which is also known to have anticancer activity in osteosarcoma cell lines, was introduced as a possible cationic species that could act as a counterpart for the decavanadate anion. However, the isolated compound contains the previously reported vanadium (V) dioxido-tpma moieties, and the decavanadate anion appears to be diprotonated. The structural characterization of the compound was performed by infrared spectroscopy and single-crystal X-ray diffraction. In addition, DFT calculations were used to analyze the reactive sites involved in the donor-acceptor interactions from the molecular electrostatic potential maps. The level of theory mPW1PW91/6–31G(d)-LANL2DZ and ECP = LANL2DZ for the V atom was used. These insights about the compounds’ main interactions were supported by analyzing the noncovalent interactions utilizing the AIM and Hirshfeld surfaces approach. Molecular docking studies with small RNA fragments were used to assess the hypothesis that decavanadate’s anticancer activity could be attributed to its interaction with lncRNA molecules. Thus, a combination of three potentially beneficial components could be evaluated in various cancer cell lines.

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“…The decavanadate compounds have shown a strong affinity for certain kinases, phosphorylase and reverse transcriptase [6] . In previous works we have published several decavanadate structures such as: Na 5.22 Li 0.78 [V 10 O 28 ]20H 2 O [7] , [Zn( [8] , we have also published articles which show the important biological activity of decavanadate compounds studied by Aissa et al [9] , Ksiksi et al [10] and Louati et al [11] . The study of the antitumor activities of these compounds encouraged us to synthesize new pure decavanadate phases and to study their structures.…”

Section: Introductionmentioning

confidence: 99%

Structure, Physic-chemical Characterizations and Hirshfeld Surface Analysis of [C7ON2H18]3V10O28·2H2O Compound

Ksiksi,

Zid,

Graia

2022

J Mod Nanotechnol

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Objective: Structural study and physico-chemical characterization of a new decavanadate compound. Methods:The compound was synthesized using distilled water as solvent. By stirring and magnetic heating and by evaporation at room temperature, a good quality crystal was chosen for single crystal X-ray diffraction.Results: A new decavanadate compound, tri [2-[2-(dimethylamino) ethyl-methylaminium]ethanol] decavanadate dehydrate, was synthesized by slow evaporation, the formula unit is composed by one decavanadate cluster, three [C 7 ON 2 H 18 ] 2+ organic cations and two water molecules. Different characterization techniques are used such as: crystal X-ray diffraction, Scanning electron microscopy with energy dispersive X-Ray analysis and thermal analysis. The X-ray structure determination revealed that the compound crystallizes in the triclinic system, space group P-1 with the cell parameters: a=10.815 (9) Å, α=112.97 (3)°, b=11.624 (4) Å, β=111.73 (7)°, c=11.840 (5) Å, γ= 96.86 (6)° and V=1195.8 (6) Å3. The cohesion of the structure is ensured by hydrogen bonds of the type O-H...O, N-H...O and van der Waals interactions. The study of the Hirshfeld surface of the decavanadate compound shows us that it is dominated by O…H/H…O (56.7%) and H…H (30.2%) type contacts. Conclusion:A new decavanadate compound was synthesized and characterized by different physicochemical techniques. The detailed structural study shows that the different groupings of the structure pile up in layers parallel to the planes (010). The cohesion of the structure is ensured by hydrogen bonds and van der Waals interactions.

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Synthesis, structural characterization and antitumoral activity of (NH4)4Li2V10O28.10H2O compound

Cited by 15 publications

References 18 publications

2-Aminopyrimidinium Decavanadate: Experimental and Theoretical Characterization, Molecular Docking, and Potential Antineoplastic Activity

2-Aminopyrimidinium Decavanadate: Experimental and Theoretical Characterization, Molecular Docking, and Potential Antineoplastic Activity

Tris(2-Pyridylmethylamine)V(O)2 Complexes as Counter Ions of Diprotonated Decavanadate Anion: Potential Antineoplastic Activity

Structure, Physic-chemical Characterizations and Hirshfeld Surface Analysis of [C7ON2H18]3V10O28·2H2O Compound

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