Synthesis, structural characterization and biological studies of some nalidixic acid–metal complexes: Metalloantibiotic complexes of some divalent and trivalent metal ions

Nickel(II)-Complex of Ceftibuten Dihydrate: Synthesis, Characterization and Thermal Study

“…In case of hydrated complex, water loss always takes place relatively at higher temperature (above 150 o C) than uncoordinated complex. 28 Kumar et al showed similar degradation pattern in TGA curve of Fe(II) and Ni(II) complex of penicillin G and ciprofloxacin. 29 Tahia et al also showed a different degradation pattern of metallodrug, from its parent drug, levofloxacin.…”

Computational analysis, Urbach energy and Judd–Ofelt parameter of warm Sm3+complexes having applications in photovoltaic and display devices

“…The aromatic proton signal of L is present in their expected regions of spectrum at 7.60 ppm, 8.61 ppm and 9.18 ppm. 47 Moreover, a little deviation and broadness in the proton signal shown by the proton NMR spectra of complexes as compared to L is due to the paramagnetic behaviour of Sm 3+ ions. 48 ·The comparison between the 13 C-NMR (DMSO-d 6 ) spectra of free L and title complexes is illustrated in Fig.…”

Bacterial Nosocomial Infections: Multidrug Resistance as a Trigger for the Development of Novel Antimicrobials

“…Moreover, the antimicrobial activity was improved after synthesizing the more water-soluble complex Au(CH 3 COO) 2 (damp), especially against S. aureus and E. faecalis [ 86 ]. Reduced polarity and higher lipophilicity were also suggested to facilitate the passage of Au(III) complexes through the lipid bilayer, allowing them to inactivate diverse essential cellular enzymes, and consequently resulting in higher antimicrobial activity [ 87 ]. This was observed by comparing the antimicrobial activity of a Au(III) complex containing a quinolone ligand—a nalidix complex ([Au(nix)(Cl) 2 ]) with the Ca(II), Fe(III), and Pd(II) analog complexes, standard drugs (tetracycline and amphotericin B), and the free ligand [ 87 ].…”

“…Reduced polarity and higher lipophilicity were also suggested to facilitate the passage of Au(III) complexes through the lipid bilayer, allowing them to inactivate diverse essential cellular enzymes, and consequently resulting in higher antimicrobial activity [ 87 ]. This was observed by comparing the antimicrobial activity of a Au(III) complex containing a quinolone ligand—a nalidix complex ([Au(nix)(Cl) 2 ]) with the Ca(II), Fe(III), and Pd(II) analog complexes, standard drugs (tetracycline and amphotericin B), and the free ligand [ 87 ]. Other gold complexes that were described as displaying remarkable antibacterial activity were the tetrachloroaurate (III) complex [(H 2 thioterpy)Cl(AuCl 4 )] and the bisdithiolate Au(III) complexes [NBu 4 ][Au(cdc) 2 ] (where cdc = cyanodithioimidocarbonate), [PPh 4 ][Au(qdt) 2 ] (where qdt = quinoxaline-2,3-dithiolate), and [NEt 4 ][Au(Et-thiazdt) 2 ] (where thiazdt = N -alkyl-1,3-thiazoline-2-thione dithiolate) [ 88 , 89 , 90 ].…”