Synthesis, structural characterization and evaluation of catalytic and antimicrobial properties of new mononuclear Ag(I), Mn(II), Cu(II) and Pt(IV) complexes

Ali, Omyma A.M.; –Wahab, Zeinab H. Abd El; Ismail, Basmh A.

doi:10.1016/j.molstruc.2017.03.025

Cited by 10 publications

(8 citation statements)

References 40 publications

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“…In the complexes these bands were shifted to lower wavelengths as an outcome of coordination when binding with metal, thus con rming the formation of Schiff base metal complexes (Table 3) [43]. The diffuse re ectance spectrum of the Co(II) complex, exhibits two peaks at 614 and 698 nm assigned to the transition 4 T 1g (F)→ 4 T 2g (F) and 4 T 1g (F)→ 4 A 2g (F), respectively suggesting an octahedral geometry for this complex [44].…”

Section: Diffuse Re Ectance Spectramentioning

confidence: 63%

Structural Characterization, DFT Calculations, Metal Uptake, Fluorescence, Antimicrobial and Molecular Docking Studies of Novel Co(II) and Ni(II) Complexes with NNS Tridentate Schiff base Ligand

Ali

Nassar

Shehata

et al. 2022

Preprint

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A new Schiff base ligand N2-((5-methylthiophen-2-yl) methylene) pyridine-2,6-diamine (L) was prepared by condensation of 5-Methyl-2-thiophenecarboxaldehyde and 2,6-diaminopyridine in ethanol in a molar ratio 1:1. The ligand and its complexes were characterized based on elemental analyses, molar conductance, magnetic moment, IR, MS, 1H NMR, solid reflectance, and thermal analysis (TG and DTG) techniques. The complexes were found to have the formulas [CoL(H2O) Cl2].H2O and [NiL(H2O)Cl2].2H2O. From FTIR spectral data, the coordination between the ligand L to the central metal ion was through its nitrogen of pyridyl and azomethine and sulfur of 2-thiophenecarboxaldehyde. The metal complexes were found to be nonelectrolyte. Octahedral geometries of the Co(II) and Ni(II) complexes were investigated from electronic and magnetic data. The kinetic analysis of the thermogravimetric data was performed by using the Coats-Redfern equation. The fluorescence properties of the ligand and its complexes in DMF were studied. The values of optical band gap energy (Eg) of the synthesized complexes suggested that these compounds could be used as semiconductors. The adsorption of Co2+ and Ni2+ in aqueous solutions on ligand under various conditions was studied. The maximum adsorption percentage of Co(II) and Ni(II) were found to be 68% and 65%, respectively. The Molecular docking studies were executed to consider the nature of binding and binding affinity of the synthesized compounds with the receptor of Bacillus subtilis (gram +ve bacteria) and Escherichia coli (gram –ve bacteria) (PDB ID: 1fj4). The ligand and its complexes were tested as antimicrobial agents.

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Section: Diffuse Re Ectance Spectramentioning

confidence: 63%

Structural Characterization, DFT Calculations, Metal Uptake, Fluorescence, Antimicrobial and Molecular Docking Studies of Novel Co(II) and Ni(II) Complexes with NNS Tridentate Schiff base Ligand

Ali

Nassar

Shehata

et al. 2022

Preprint

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“…It is well‐known that the metal complexes are more effective in catalytic decomposition of hydrogen peroxide. [ 25 ] In this study, decomposition of H 2 O 2 was catalyzed by titled complexes, while the reaction progress was monitoring by titrating against potassium permanganate.…”

Section: Resultsmentioning

confidence: 99%

“…Catalase is responsible for the catalytic decomposition of hydrogen peroxide through disproportionation into nontoxic dioxygen and water. [ 25,26 ] Many metal‐based complexes have been used to mimic several enzymes, for example, superoxide dismutase, catalase, and so on. [ 27–30 ]…”

Section: Introductionmentioning

confidence: 99%

“…Catalase is responsible for the catalytic decomposition of hydrogen peroxide through disproportionation into nontoxic dioxygen and water. [25,26] Many metal-based complexes have been used to mimic several enzymes, for example, superoxide dismutase, catalase, and so on. [27][28][29][30] The formation and characteristics of mixed-ligand complexes have received much attention, as they represent new materials for enhancement biological and catalytic features.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, structural elucidation, and density functional theory investigation of new mononuclear Fe(III), Ni(II), and Cu(II) mixed‐ligand complexes: Biological and catalase mimicking activity exploration

Abdou

Abdel‐Mawgoud

2022

Applied Organom Chemis

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The present paper deals with synthesis new mononuclear 1:1:1 metal:ligand:co‐ligand complexes, FeLG, NiLG, and CuLG, where L = 1‐{(E)‐[(4‐methylphenyl)imino]methyl}‐2‐naphthol and G = Glycine. The synthesized complexes were characterized based on elemental analysis, Fourier transform infrared spectroscopy (FT‐IR), ultraviolet–visible (UV–vis), mass spectra, molar conductance, magnetic susceptibility, and thermal analysis (TGA) in addition to stoichiometry determination via molar ratio method. The isolated metal complexes showed interesting geometry variation as tetrahedral for CuLG and octahedral for both FeLG and NiLG. The molecular structures of the titled compounds were optimized theoretically using density functional theory (DFT) approach, and the quantum chemical descriptors were calculated. The disk diffusion method was used to investigate the growth inhibition of the titled compounds aganist selected pathogenic bacterial and fungal strains. The metal complexes exhibited higher enhancement as antimicrobial candidates with lower minimum inhibitory concentration (MIC) than the free ligands, and in some cases, the complexes were closed to the standard species. Molecular docking investigation was carried out to ascertain the inhibitory action of the studied compounds against 1HNJ protein, the target enzyme for the antimicrobial agents. The results indicated that the FeLG has the highest binding affinity in comparison with other compounds. Thus, these molecules could be promising antimicrobial candidates. Furthermore, catalase mimicking activity of the complexes has been investigated. The data revealed that CuLG complex catalyzes the decomposition of hydrogen peroxide most effectively. Finally, the quantum chemical parameters of the titled complexes and other different compounds were correlated with their practical biological activity data in a trial to build a SAR model.

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“…Recently mixed ligand complexes of manganese, iron, cobalt and nickel with N,O donor Schiff base and bipyridyl like 1, 10-phenanthroline have attracted great interest, owing to their RESEARCH ARTICLE significant roles in the advancement of biomedicine 1 , bio-sensors 2 , corrosion inhibitors 3 , model compounds for active centers of metalloenzymes 4 and in homogeneous and heterogeneous catalytic reactions of industrial importance 5 . These complexes have also exhibits wide range of biological and pharmaceutical activities that include antimicrobial, antituberculosis, antiinflammatory, anticancer and antioxidant behavior 6,7 .…”

Section: Introductionmentioning

confidence: 99%

Bio-Mimetic Catalase-like Activity, Corrosion Inhibition, Antibacterial, DFT and Spectroscopic Characterization of Mixed Ligand Complexes of 1,10-Phenanthroline with Dibasic Benzoin Schiff Base Ligand

2018

Chem Sci Trans

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Four novel mix ligand complexes of manganese(II), iron(III), cobalt(II) and nickel(II) with dibasic tetra dentate Schiff base ligand BENZOEN and 1, 10-phenanthroline have been synthesized with the general composition of [M(BENZOEN)(1,10-phen)], where M = Mn(II), Co(II), Ni(II) and [Fe(BENZOEN)(1,10-phen)]Cl. The synthesized ligand and complexes were characterized on the basis of elemental analysis, molar conductance, magnetic susceptibility, ESI-MS spectrometry, electronic spectra, FT-IR, 1 H NMR and 13 C NMR spectroscopy. Theoretical computation and combined experimental theoretical characterization were carrying out by Gaussian 09 software package using density functional theory (DFT) method to confirm the geometry of the investigated compounds. Additionally, molecular electrostatic potential map (MEP), HOMO, LUMO, NBO and Mullikan charge analysis were also been performed. Spectroscopic chracterization and DFT study proposed a distorted octahedral structure of complex 1-4. In vitro biomimetic catalase activity of the ligand and complexes was done by measuring amount of dioxygen evolve. Saturation kinetics of H 2 O 2 decomposition was fitted to the Michaelis-Menten equation and Lineweaver-Burk plot. The antibacterial activity of the ligand and complexes against Escherichia coli shows complexes were found more potent than the BENZOEN. MIC of complexes shows that complex 2 is more active than other complexes even at lower concentration.

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Synthesis, structural characterization and evaluation of catalytic and antimicrobial properties of new mononuclear Ag(I), Mn(II), Cu(II) and Pt(IV) complexes

Cited by 10 publications

References 40 publications

Structural Characterization, DFT Calculations, Metal Uptake, Fluorescence, Antimicrobial and Molecular Docking Studies of Novel Co(II) and Ni(II) Complexes with NNS Tridentate Schiff base Ligand

Structural Characterization, DFT Calculations, Metal Uptake, Fluorescence, Antimicrobial and Molecular Docking Studies of Novel Co(II) and Ni(II) Complexes with NNS Tridentate Schiff base Ligand

Synthesis, structural elucidation, and density functional theory investigation of new mononuclear Fe(III), Ni(II), and Cu(II) mixed‐ligand complexes: Biological and catalase mimicking activity exploration

Bio-Mimetic Catalase-like Activity, Corrosion Inhibition, Antibacterial, DFT and Spectroscopic Characterization of Mixed Ligand Complexes of 1,10-Phenanthroline with Dibasic Benzoin Schiff Base Ligand

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