Synthesis, structural characterization, oxygen sensitivity, and antimicrobial activity of ruthenium(II) carbonyl complexes with thiosemicarbazones

Influence of Halogen Substitution in the Ligand Sphere on the Antitumor and Antibacterial Activity of Half-sandwich Ruthenium(II) Complexes [RuX(η6 -arene)(C5 H4 N-2-CH=N-Ar)]+

“…In addition, the complexes showed better activity when compared to the ruthenium(III) complexes reported by Sathya and co‐workers, the ruthenium(III) complexes containing ONO donor ligands and ruthenium(II) carbonyl complexes with thiosemicarbazone ligands . In addition, the complexes' activity was comparable to the ruthenium(II) complexes with mono‐nucleating tetradentate ligands reported by Arunachalam and co‐workers …”

Study of Radiotherapy Properties and Antimicrobial Activity of Glyconanoparticles (GNPs) Generated from Imidazolium Salts

“…Many studies on the antimicrobial properties of amino sugars derived from chloraloses, monosaccharide‐containing Schiff base ligands and complexes have been reported in the literature [59–61] . Within this study, determination of the antimicrobial activities of the sugar based imidazoles ( 1 a – c ) and their IMSs ( 2 a – c ) was carried out in vitro by using the disc diffusion method [61–63] against bacterial strains of Gram‐negative organisms ( Escherichia coli (clinical isolate), Pseudomonas aeruginosa (clinical isolate), Pseudomonas aeruginosa ATCC 27853, Escherichia coli ATCC 25922 and Enterobacter cloacae ATCC 23355) and Gram‐positive organisms ( Staphylococcus aureus (clinical isolate), Bacillus subtilis ATCC 11774 and Staphylococcus aureus ATCC 25923), and unicellular yeast C. albicans ATCC 10231. The antibacterial and antifungal activities were utilized by measuring the inhibition zone diameter observed.…”

“…In contrast, bacterial outer cell walls and membranes are generally negatively charged because of the presence of negatively charged components (phospholipids, teichoic acids, and lipopolysaccharides) [58,60,62] . Therefore, new antibacterial drugs are generally designed to have a cationic component to increase selectivity [58,61–63] …”

“…[58,60,62] Therefore, new antibacterial drugs are generally designed to have a cationic component to increase selectivity. [58,[61][62][63] Under the light of the literature survey, the antimicrobial activity of GNPs (AuNP-Cyt-2 b and AgNP-Cyt-2 b) as well as bare AuNPs and AgNPs were also assessed via the disc diffusion test method against the test microorganisms stated in Table 2. However, neither AuNP-Cyt-2 b and AgNP-Cyt-2 b nor bare metallic NPs showed any activity against Gram-positive and Gram-negative bacteria, as well as yeast C. albicans ATCC 10231 at the concentration studied in this work (data are not included in Table 2).…”

Half-Sandwich Arene Ruthenium(II) Thiosemicarbazone Complexes: Evaluation of Anticancer Effect on Primary and Metastatic Ovarian Cancer Cell Lines

“…New ligands L = 5-nitro-2-carboxyaldehydethiophen- N -methyl-thiosemicarbazone, (L1); 2-acetyl-5-bromo-thiophen- N -methyl-thiosemicarbazone, (L2) and 2-acetyl-5-bromo-thiophen- N, N -dimethyl-thiosemicarbazone, (L3) were synthesized according to described procedures ( Yildirim et al, 2014 ; Öztürk et al, 2014 ; Dömötör et al, 2018 ; Tavsan et al, 2018 ; Subasi et al, 2020 ). Then half-sandwich arene Ru(II) complexes (I−III) of the general formula Ru [(η 6 - p -cym) ( N, S -L)Cl]Cl were isolated in good yields.…”