Synthesis, structural elucidation and biological activities of organotin(IV) derivatives of (E)-3-(4-methoxyphenyl)-2-(4-chlorophenyl)-2-propenoic acid

Organotin(IV) Carboxylates of Substitutedα‐Cinnamic Acid, RnSn(OCOC(R2)=CHR1)4 –n: Synthesis, Spectroscopic Characterization and Biological Evaluation

“…A broad and strong band associated with the hydroxyl (OH) group of the phenolic ring of ligand moiety is observed in the range 3380–3122 cm −1 , which rules out any coordination to the Sn atom via phenolic OH . The data obtained are consistent with the formation of well‐defined diorganotin(IV) 1 , 3 , 4 and triorganotin(IV) 2 , 5 , 6 complexes, which is confirmed by the presence of υ(Sn–O) and υ(Sn–C) bands in the range of 475–459 and 580–553 cm −1 , respectively, and shifting of υ(COO) bands to lower frequencies for all the complexes . The difference of Δυ between υ(COO) asym and υ(COO) sym vibrations gives important information about the molecular arrangement in such complexes.…”

“…Antifungal activity also differs from the analogous organotin(IV) complexes of other substituted cinnamic acids. This may be due to the fore mentioned reasons discussed above .…”

“…As cinnamic acid derivatives especially with hydroxyl groups are known for their promising biological properties and potential for drug development, with its C 6 –C 3 framework, the antioxidant behavior through the reactive oxygen species scavenging ability is another area of interest [d]. Owing to these diverse properties of substituted cinnamic acid, biological potential of organotin(IV) carboxylates, and being active participants in this field [], we now report on the synthesis, characterization, and biocidal activity of the newly synthesized organotin(IV) compounds with ( E )‐3‐(4‐hydroxy‐3‐methoxyphenyl)‐2‐phenylpropenoic acid (Fig. ).…”

Organotin(iv) carboxylate derivatives as a new addition to anticancer and antileishmanial agents: design, physicochemical characterization and interaction with Salmon sperm DNA

“…The other two pathways aer primary elimination of [R] + and [R 3 Sn] + groups and then elimination of COO and successive R (in one of the pathway) results in the formation of [R 0 ] + (Scheme 3), which shows a similar pattern for the further elimination of different groups. 55 A slightly different scheme for the mass fragmentation pattern has been suggested for the diorganotin compounds (Scheme 4) but these pathways end up in a similar way to those suggested for the triorganotin compounds. In addition, the following ions: [C 4 a Symmetry transformations used to generate equivalent atoms for complex: 1 À1 + x, +y, 1 + z. Symmetry transformations used to generate equivalent atoms for complex: 3 (i) +x, À1/2 À y, À1/2 + z, complex: 4 (i) 1 + x, +y, +z; (ii) Àx, 1/2 + y, 1 À z.…”