Search citation statements
Paper Sections
Citation Types
Year Published
Publication Types
Relationship
Authors
Journals
Self-assembly of (((1-(pyridin-2-yl)ethylidene)hydrazono)methyl)phenol ligand (L 1 ) and MnCl 2 proceeded with the hydrolysis of the ligand affording the new [Mn(L 2 )Cl 2 ] n 1D coordination polymer where L 2 is 2-(1-hydrazonoethyl)pyridine. The structure of [Mn(L 2 )Cl 2 ] n was confirmed using FTIR, CHN, and Xray diffraction of single crystal. It crystallized in the triclinic P-1 crystal system with a = 7.0697(9) Å, b = 8.878(1) Å, c = 9.402(2) Å, α = 113.99(2) , β = 95.48(1) , γ = 111.77(1) , and V = 479.13(15) Å 3 . The Mn(II) is octahedrally coordinated with two nitrogen atoms from L 2 and four chloride ions. The chloride anions act as bridging ligand that connect the Mn(II) centers leading to the formation of the 1D polymer. Based on continuous shape (CShM) measure tool, the coordination configuration is closer to the octahedron rather than a trigonal prism. Using Hirshfeld analysis, the Cl … H (29.2%), H … C (13.6%), and C … C (3.7%) contacts are the most important in the molecular packing of [Mn(L 2 )Cl 2 ] n complex. The ligand L 2 has better antibacterial, antifungal, and antioxidant activities than the Mn(II) complex. The [Mn(L 2 )Cl 2 ] n complex has higher cytotoxic effect than L 2 against both lung carcinoma A-549 and lung fibroblast MRC-5 cell lines. The IC 50 and CC 50 values of the Mn(II) complex are 26.09 ± 1.76 and 60.40 ± 3.74 μg ml À1 , respectively, while 121.23 ± 5.91 and 241.13 ± 13.29 μg ml À1 , respectively, for L 2 . K E Y W O R D Santi-cancer agent, hydrazone, Mn(II) complex, Schiff bases, self-assembly | INTRODUCTIONSchiff bases are compounds generated from the reaction of aldehydes or ketones with compounds carrying amino group. These compounds are being significantly consumed as ligands for the production of numerous types of metal complexes. [1][2][3] Schiff bases and their complexes are known to have interesting catalytic and biological activities. The activity is influenced by complexation of the Schiff base ligand with metals, which can result in the synthesis of new different compounds with several applications in the chemical industry, for both organic synthesis and the pharmaceutical industry. [4][5][6][7][8] Recently, significant attention has been given to arylhydrazone Schiff base ligands since they contain a range of donor atoms that give them a unique potential to bind
Self-assembly of (((1-(pyridin-2-yl)ethylidene)hydrazono)methyl)phenol ligand (L 1 ) and MnCl 2 proceeded with the hydrolysis of the ligand affording the new [Mn(L 2 )Cl 2 ] n 1D coordination polymer where L 2 is 2-(1-hydrazonoethyl)pyridine. The structure of [Mn(L 2 )Cl 2 ] n was confirmed using FTIR, CHN, and Xray diffraction of single crystal. It crystallized in the triclinic P-1 crystal system with a = 7.0697(9) Å, b = 8.878(1) Å, c = 9.402(2) Å, α = 113.99(2) , β = 95.48(1) , γ = 111.77(1) , and V = 479.13(15) Å 3 . The Mn(II) is octahedrally coordinated with two nitrogen atoms from L 2 and four chloride ions. The chloride anions act as bridging ligand that connect the Mn(II) centers leading to the formation of the 1D polymer. Based on continuous shape (CShM) measure tool, the coordination configuration is closer to the octahedron rather than a trigonal prism. Using Hirshfeld analysis, the Cl … H (29.2%), H … C (13.6%), and C … C (3.7%) contacts are the most important in the molecular packing of [Mn(L 2 )Cl 2 ] n complex. The ligand L 2 has better antibacterial, antifungal, and antioxidant activities than the Mn(II) complex. The [Mn(L 2 )Cl 2 ] n complex has higher cytotoxic effect than L 2 against both lung carcinoma A-549 and lung fibroblast MRC-5 cell lines. The IC 50 and CC 50 values of the Mn(II) complex are 26.09 ± 1.76 and 60.40 ± 3.74 μg ml À1 , respectively, while 121.23 ± 5.91 and 241.13 ± 13.29 μg ml À1 , respectively, for L 2 . K E Y W O R D Santi-cancer agent, hydrazone, Mn(II) complex, Schiff bases, self-assembly | INTRODUCTIONSchiff bases are compounds generated from the reaction of aldehydes or ketones with compounds carrying amino group. These compounds are being significantly consumed as ligands for the production of numerous types of metal complexes. [1][2][3] Schiff bases and their complexes are known to have interesting catalytic and biological activities. The activity is influenced by complexation of the Schiff base ligand with metals, which can result in the synthesis of new different compounds with several applications in the chemical industry, for both organic synthesis and the pharmaceutical industry. [4][5][6][7][8] Recently, significant attention has been given to arylhydrazone Schiff base ligands since they contain a range of donor atoms that give them a unique potential to bind
A series of novel 2,3,5‐trisubstituted thiazolidinone derivatives was designed and synthesized. Compounds were tested for their antimicrobial and antitubercular activities. Compounds 3‐(2,4‐difluorobenzyl)‐5‐[(5‐methylfuran‐2‐yl)methylidene]‐2‐(phenylimino)‐1,3‐thiazolidin‐4‐one (5 c) and 3‐(2,4‐difluorobenzyl)‐2‐((3‐fluorophenyl)imino)‐5‐((Z)‐4‐hydroxybenzylidene) thiazolidin‐4‐one (6 f) exhibited remarkable antimicrobial activity against Klebsiella pneumoniae and Escherichia coli respectively. All compounds except 3‐(2,4‐difluorobenzyl)‐5‐((3‐(4‐fluorophenyl)‐1‐phenyl‐1H‐pyrazol‐4‐yl)methylene)‐2‐(phenylimino)thiazolidin‐4‐one (5 a) and (6 f) exposed excellent antitubercular activity in comparison with the standard drugs against H37RV strain of Mycobacterium tuberculosis (ATCC No‐ 27294). In addition, molecular docking and dynamic simulations studies were performed with E. coli Mur B (EMB) (PDB ID: 2Q85), Aspergillus fumigatus sterol 14‐alpha demethylase (ASD) (PDB ID: 4UYM) and Mycobacterium tuberculosis pantothenate synthetase (MPS) (PDB ID: 3IVX) proteins against all compounds and the most potent compound (5 c) displayed higher binding proficiency. These compounds may serve as lead compounds for further optimization to achieve promising therapeutic properties.
A series of 2,3-dihydroquinazolin-4(1H)-one derivatives (3a–3m) was screened for in vitro whole-cell antitubercular activity against the tubercular strain H37Rv and multidrug-resistant (MDR) Mycobacterium tuberculosis (MTB) strains. Compounds 3l and 3m with di-substituted aryl moiety (halogens) attached to the 2-position of the scaffold showed a minimum inhibitory concentration (MIC) of 2 µg/mL against the MTB strain H37Rv. Compound 3k with an imidazole ring at the 2-position of the dihydroquinazolin-4(1H)-one also showed significant inhibitory action against both the susceptible strain H37Rv and MDR strains with MIC values of 4 and 16 µg/mL, respectively. The computational results revealed the mycobacterial pyridoxal-5′-phosphate (PLP)-dependent aminotransferase (BioA) enzyme as the potential target for the tested compounds. In vitro, ADMET calculations and cytotoxicity studies against the normal human dermal fibroblast cells indicated the safety and tolerability of the test compounds 3k–3m. Thus, compounds 3k–3m warrant further optimization to develop novel BioA inhibitors for the treatment of drug-sensitive H37Rv and drug-resistant MTB.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2025 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.