Synthesis, structure and anti-cancer activity of osmium complexes bearing π-bound arene substituents and phosphane Co-Ligands: A review

Nabiyeva, Tomiris; Marschner, Christoph; Blom, Burgert

doi:10.1016/j.ejmech.2020.112483

Cited by 35 publications

(19 citation statements)

References 134 publications

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“…As a result, osmium complexes have become versatile with great promise for utility in cancer treatment, including light-activated cancer therapy and photodynamic therapy [68,69]. The anticancer effects of osmium complexes are succinctly discussed in the reviews by Hanif et al [70], Meier-Menches et al [71], and Nabiyeva et al [72]. Examples of osmium complexes that demonstrate antiproliferative effects include the Os(II/III) analogues (72) of the well-studied Ru(II/III) RAPTA complexes shown in Figure 18 [72].…”

Section: Osmium Complexesmentioning

confidence: 99%

“…The anticancer effects of osmium complexes are succinctly discussed in the reviews by Hanif et al [70], Meier-Menches et al [71], and Nabiyeva et al [72]. Examples of osmium complexes that demonstrate antiproliferative effects include the Os(II/III) analogues (72) of the well-studied Ru(II/III) RAPTA complexes shown in Figure 18 [72]. generation of ROS, within the pathogenic cells of the targeted disease [66].…”

Section: Osmium Complexesmentioning

confidence: 99%

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Recent Advances in the Biological Investigation of Organometallic Platinum-Group Metal (Ir, Ru, Rh, Os, Pd, Pt) Complexes as Antimalarial Agents

2020

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In the face of the recent pandemic and emergence of infectious diseases of viral origin, research on parasitic diseases such as malaria continues to remain critical and innovative methods are required to target the rising widespread resistance that renders conventional therapies unusable. The prolific use of auxiliary metallo-fragments has augmented the search for novel drug regimens in an attempt to combat rising resistance. The development of organometallic compounds (those containing metal-carbon bonds) as antimalarial drugs has been exemplified by the clinical development of ferroquine in the nascent field of Bioorganometallic Chemistry. With their inherent physicochemical properties, organometallic complexes can modulate the discipline of chemical biology by proffering different modes of action and targeting various enzymes. With the beneficiation of platinum group metals (PGMs) in mind, this review aims to describe recent studies on the antimalarial activity of PGM-based organometallic complexes. This review does not provide an exhaustive coverage of the literature but focusses on recent advances of bioorganometallic antimalarial drug leads, including a brief mention of recent trends comprising interactions with biomolecules such as heme and intracellular catalysis. This resource can be used in parallel with complementary reviews on metal-based complexes tested against malaria.

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Section: Osmium Complexesmentioning

confidence: 99%

Section: Osmium Complexesmentioning

confidence: 99%

Recent Advances in the Biological Investigation of Organometallic Platinum-Group Metal (Ir, Ru, Rh, Os, Pd, Pt) Complexes as Antimalarial Agents

2020

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“…These unresolved issues call for novel therapeutic options and the use of alternative solutions, such as organometallic complexes of other platinum-group metals. There are numerous complexes of ruthenium [ 1 , 8 , 9 , 10 , 11 , 12 , 13 , 14 ], osmium [ 2 , 9 , 12 , 13 , 14 , 15 , 16 , 17 ], rhodium [ 13 , 18 , 19 ], or iridium [ 2 , 12 , 13 , 18 , 20 ] that are used in oncological settings. In fact, one ruthenium complex, IT-139, has passed clinical phase-I studies and is intended for use in colorectal cancer [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Reactive Oxygen Species Production Is Responsible for Antineoplastic Activity of Osmium, Ruthenium, Iridium and Rhodium Half-Sandwich Type Complexes with Bidentate Glycosyl Heterocyclic Ligands in Various Cancer Cell Models

Kacsir

Sipos

Bényei

et al. 2022

IJMS

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Platinum complexes are used in chemotherapy, primarily as antineoplastic agents. In this study, we assessed the cytotoxic and cytostatic properties of a set of osmium(II), ruthenium(II), iridium(III) and rhodium(III) half-sandwich-type complexes with bidentate monosaccharide ligands. We identified 5 compounds with moderate to negligible acute cytotoxicity but with potent long-term cytostatic activity. These structure-activity relationship studies revealed that: 1) osmium(II) p-cymene complexes were active in all models, while rhodium(III) and iridium(III) Cp* complexes proved largely inactive; 2) the biological effect was influenced by the nature of the central azole ring of the ligands—1,2,3-triazole was the most effective, followed by 1,3,4-oxadiazole, while the isomeric 1,2,4-oxadiazole abolished the cytostatic activity; 3) we found a correlation between the hydrophobic character of the complexes and their cytostatic activity: compounds with O-benzoyl protective groups on the carbohydrate moiety were active, compared to O-deprotected ones. The best compound, an osmium(II) complex, had an IC50 value of 0.70 µM. Furthermore, the steepness of the inhibitory curve of the active complexes suggested cooperative binding; cooperative molecules were better inhibitors than non-cooperative ones. The cytostatic activity of the active complexes was abolished by a lipid-soluble antioxidant, vitamin E, suggesting that oxidative stress plays a major role in the biological activity of the complexes. The complexes were active on ovarian cancer, pancreatic adenocarcinoma, osteosarcoma and Hodgkin’s lymphoma cells, but were inactive on primary, non-transformed human fibroblasts, indicating their applicability as potential anticancer agents.

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“…Metal complexes capable of undergoing intracellular redox reactions are promising alternative anticancer treatments to Pt(II) agents, which bind to DNA and are currently used in the clinic. [1][2][3][4][5][6][7][8][9][10][11][12] Such drug candidates include inert prodrugs that are activated through metal reduction (i.e. Pt(IV) or Ru(III) complexes), to redox-active complexes that modulate the redox balance in cancer cells producing reactive oxygen species (ROS), or altering the level of key cellular cofactors.…”

Section: Introductionmentioning

confidence: 99%

Elemental mapping of half-sandwich azopyridine osmium arene complexes in cancer cells

Bolitho

Bridgewater

Needham

et al. 2021

Inorg. Chem. Front.

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Synthesis, structure and anti-cancer activity of osmium complexes bearing π-bound arene substituents and phosphane Co-Ligands: A review

Cited by 35 publications

References 134 publications

Recent Advances in the Biological Investigation of Organometallic Platinum-Group Metal (Ir, Ru, Rh, Os, Pd, Pt) Complexes as Antimalarial Agents

Recent Advances in the Biological Investigation of Organometallic Platinum-Group Metal (Ir, Ru, Rh, Os, Pd, Pt) Complexes as Antimalarial Agents

Reactive Oxygen Species Production Is Responsible for Antineoplastic Activity of Osmium, Ruthenium, Iridium and Rhodium Half-Sandwich Type Complexes with Bidentate Glycosyl Heterocyclic Ligands in Various Cancer Cell Models

Elemental mapping of half-sandwich azopyridine osmium arene complexes in cancer cells

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