Synthesis, structure and antifungal properties of Co(II)–sulfathiazolate complexes

Bellú, Sebastián; Hure, Estela; Trapé, Marcela; Trossero, Claudia; Molina, Gabriel A; Drogo, Claudia; Williams, Patricia Ana María; Atria, Ana Marı́a; Acevedo, Juan Carlos Muñoz; Zacchino, Susana; Sortino, Maximilano; Campagnoli, Darío; Rizzotto, Marcela

doi:10.1016/j.poly.2004.12.017

Cited by 40 publications

(15 citation statements)

References 43 publications

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“…In the region of pH ≈ 2, out of our range of potentiometric measurements, the predominant specie would be the [Co(H 2 O) 6 ] 2+ complex, so, it is not any complex between HST and Co(II) at this pH. However, at pH ≈ 4 and pH ≈ 8, where, in agreement with potentiometric measurements, the ML and M(OH)L (where L represents ST -) are, respectively, the predominant species, the wavelength of the absorption maxima were shifted at very similar λ, suggesting that the coordination sphere might be similar in both cases and different from the [Co(H 2 O) 6 4 ], which was measured in the 400-900 nm range 65 , suggests an octahedral geometry around the metal ion 66 …”

Section: Electronic Spectrasupporting

confidence: 83%

“…Anyway, we discard this site of binding of the ligand because, although Co(II) is able to form complexes in which the metal ion is coordinated by means of O atoms, N atoms or both, in all cases these O atoms are binding to C atoms, not to S ones 68 . Besides, in two solid cobalt compounds obtained previously between sulfathiazole and Co(II) 3 ] n ), the IR bands attributed to the SO 2 vibrations remain unaltered, suggesting no interaction of the -SO 2 -group with the metal ion 65 .…”

Section: Structural Data and Topological Analysismentioning

confidence: 80%

“…Recently, we determined the crystal structure of [Co II (ST) 2 4 ] in only one water molecule-, where the cobalt atom exhibits a distorted octahedral coordination sphere, and three of the donor atoms are nitrogen: two N thiazolic and one N amine . Other donor atoms are oxygen from water molecules 65 . In the Co(II)-citric acid system 47 84 .…”

Section: Structure Of the Complexesmentioning

confidence: 99%

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The interaction between sulfathiazole and cobalt(II): potentiometric studies

Bellú¹,

Rizzotto²,

Okulik³

et al. 2007

Quím. Nova

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Recebido em 19/6/06; aceito em 17/11/06; publicado na web em 2/7/07Potentiometric studies of sulfathiazole (HST) in the presence and absence of cobalt(II) were performed. Equilibrium constants for the formation of the detected species, [Co(ST)] + and [Co(ST)(OH)], are reported. UV-Vis spectrophotometric measurements suggest that the coordination Co(II)-sulfathiazole might be through a N atom, which, in agreement with MO calculations, could be a thiazolic one. In spite of sulfonamides being better ligands at pH >7, [Co(ST)] + was found at pH ≈ 3.

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Section: Electronic Spectrasupporting

confidence: 83%

Section: Structural Data and Topological Analysismentioning

confidence: 80%

Section: Structure Of the Complexesmentioning

confidence: 99%

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The interaction between sulfathiazole and cobalt(II): potentiometric studies

Bellú¹,

Rizzotto²,

Okulik³

et al. 2007

Quím. Nova

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“…Moreover, the synthesized sulfa could possibly have topical therapeutic applications [8][9][10][11][12]17,18 .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Physicochemical Analyses, and Antibacterial Activity of the Fe(iii) Salt of 4-Amine-N-2-Thiazolyl-Benzene Sulfonamide

Bordier

Navarro

Cámpora

et al. 2014

J. Chil. Chem. Soc.

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The synthesis and characterization of the Fe(III) complex of sulfathiazole, is presented herein. The compound was prepared by using a conventional precipitation technique, and was characterized by thermogravimetric analysis (TGA), differential thermal (DTA), differential scanning calorimetry (DSC) under oxygen atmosphere, chemical analysis, infrared spectroscopy, powder ray-X diffraction (PXRD), and scanning electron microscopy (SEM). The antibacterial activity of the complex was screened against S. aureus, showing an appreciable activity, compared with the free ligand.

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“…The selected sulfonamides were: sulfathiazole (4-amino-N-2-thiazolylbencenosulfonamide), HST, which in part is absorbed in stomach, 21 and is clinically one of the most used; 24 phtalylsulfathiazole, PhST, which is structurally related with HST ( Figure 1) and the complex Co(II)- 4 ], which was lately synthesized in our laboratory and has showed a moderated antifungal activity. 25 …”

Section: Introductionmentioning

confidence: 99%

Reaction mixtures formed by nitrite and selected sulfa-drugs showed mutagenicity in acidic medium

Trossero¹,

Pontoriero²,

Hure³

et al. 2009

Quím. Nova

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Recebido em 29/4/08; aceito em 8/12/08; publicaod na web em 28/5/09Nitrite, which is present in preserved meat and can be produced in the oral cavity by reduction of nitrate taken from vegetables, could react in stomach with nitrosatable drugs, giving genotoxic-carcinogenic N-nitroso compounds (NOC). The mutagenicity of reaction mixtures formed by sodium nitrite and selected sulfa-drugs (sulfathiazole, HST; phtalylsulfathiazole, PhST; complex Co(II)-sulfathiazole, Co(II)-ST) in acidic medium was evaluated using the Salmonella typhimurium reverse mutation assay (Ames test), with TA98 and TA100 strains. The reactions were carried out at room temperature, with a mole ratio [nitrite]/[sulfa-drug] ≥ 1. The three reaction mixtures showed mutagenic effects in the considered range.

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Synthesis, structure and antifungal properties of Co(II)–sulfathiazolate complexes

Cited by 40 publications

References 43 publications

The interaction between sulfathiazole and cobalt(II): potentiometric studies

The interaction between sulfathiazole and cobalt(II): potentiometric studies

Synthesis, Physicochemical Analyses, and Antibacterial Activity of the Fe(iii) Salt of 4-Amine-N-2-Thiazolyl-Benzene Sulfonamide

Reaction mixtures formed by nitrite and selected sulfa-drugs showed mutagenicity in acidic medium

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