Synthesis, Structure, and Biological Activity of Copper(II), Nickel(II), Cobalt(III), and Iron(III) Coordination Compounds with 2-{2-[(Prop-2-en-1-yl)carbamothioyl]hydrazinylidene}propanoic Acid

Gulea, Aurélian; Graur, Vasilii; Diurici, E. C.; Ulchina, Ia. I.; Боурош, П. Н.; Bălan, Greta; Burduniuc, Olga; Tsapkov, V. I.; Valeriu, Rudic

doi:10.1134/s107036322011016x

Cited by 4 publications

(5 citation statements)

References 19 publications

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“…Such a mode of coordination was also established in previously studied Cu(II) compounds with different substituted thiosemicarbazones. 11,25,32…”

Section: Resultsmentioning

confidence: 99%

“…Such a mode of coordination was also established in previously studied Cu(II) compounds with different substituted thiosemicarbazones. 11,25,32 The Cu 1 atom in complex 1 is tetracoordinated and the copper centre exhibits a square planar coordination. The tridentate thiosemicarbazone ligand is coordinated to the central atom in the monodeprotonated form (L) − using an ONS 4, Figure 5).…”

Section: Spectroscopic Studiesmentioning

confidence: 99%

“…8,9 Pyruvic acid is a natural product found in Populus tremula , Macrobrachium nipponense , and other organisms. Pyruvic acid thiosemicarbazone and its complexes exhibit various types of biological activity: antimicrobial, 10,11 antifungal, 12,13 cytotoxic, 14 and antitumor. 15 The complexes were more active than the uncoordinated thiosemicarbazone and even exceeded the activity of medicinal compounds used as standards.…”

Section: Introductionmentioning

confidence: 99%

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A new thiosemicarbazone and its 3d metal complexes: Synthetic, structural, and antioxidant studies

Graur,

Bespalova,

Graur

et al. 2023

Journal of Chemical Research

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2-[1-Oxo-1-(piperidin-1-yl)propan-2-ylidene]- N-(prop-2-en-1-yl)hydrazinecarbothioamide (HL) and its six coordination compounds [Cu(L)X] (X = Cl− (1), NO3− (2)), [Cu(A)(L)NO3](A = 1,10-Phen (3), 2,2′-Bpy (4)), [Ni(HL)2](NO3)2 (5), and [Fe(L)2]Cl (6) are synthesized and characterized by elemental analysis, Fourier-transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), and single-crystal X-ray crystallography. Uncoordinated thiosemicarbazone HL shows higher antioxidant activity against 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS+•) cation radicals compared with most of the other complexes. Complex 5 is the most active and its activity exceeds that of HL and is close to that of trolox, which is used in medicine as an antioxidant. The introduction of N-heteroaromatic bases (1,10-phenanthroline and 2,2′-bipyridine) into the inner sphere of the complex [Cu(L)NO3] did not lead to an increase in antioxidant activity.

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“…Such a mode of coordination was also established in previously studied Cu(II) compounds with different substituted thiosemicarbazones. 11,25,32…”

Section: Resultsmentioning

confidence: 99%

Section: Spectroscopic Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A new thiosemicarbazone and its 3d metal complexes: Synthetic, structural, and antioxidant studies

Graur,

Bespalova,

Graur

et al. 2023

Journal of Chemical Research

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“…[1][2][3][4][5] Thiosemicarbazones coordinate to the metal ions forming stable coordination compounds whose biological properties differ from the properties of the initial uncoordinated thiosemicarbazone. [6][7][8][9][10] Copper is an essential trace metal found in all living organisms. It is found in all body tissues and plays a role in making red blood cells and maintaining nerve cells and the immune system.…”

Section: Introductionmentioning

confidence: 99%

“…Thiosemicarbazones coordinate to the metal ions forming stable coordination compounds whose biological properties differ from the properties of the initial uncoordinated thiosemicarbazone [6–10] …”

Section: Introductionmentioning

confidence: 99%

Introducing N‐Heteroaromatic Bases into Copper(II) Thiosemicarbazon Complexes: A Way to Change their Biological Activity

et al. 2022

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Three new copper(II) complexes, [Cu(1,10-Phen)(L)] (1), [Cu(2,2'-Bpy)(L)] ( 2) and [Cu(3,,10-Phen = 1,10-phenanthroline, 2,2'-Bpy = 2,2'-bipyridine, 3,4-Lut = 3,4-lutidine, have been synthesized and characterized by elemental analysis, FTIR spectroscopy and single crystal X-ray crystallography (1, 2). All compounds are mononuclear. The introduction of a monodentate N-heteroaromatic base (3,4-dimethylpyridine) has led to a significant increase of antimicrobial activity against Gram-negative Escherichia coli and antifungal activity against Candida albicans compared to the pro-ligand and the precursor complex [Cu-(L)H 2 O]. The introduction of bidentate N-heteroaromatic bases did not lead to such increase of antimicrobial and antifungal activities. Moreover, complex 3 surpasses the inhibitory activity of tetracycline toward Enterobacter cloacae and the inhibitory activity of fluconazole toward Candida parapsilosis and Cryptococcus neoformans. The study of antioxidant activity against cation radicals ABTS * + showed that complexes 1-3 are more active than Trolox, but only introduction of the monodentate Nheteroaromatic base (3,4-dimethylpyridine) led to the increase of antioxidant properties compared to the precursor complex.

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Six-coordinated complexes of Co(II), Ni(II) and Cu(II) chlorides with N-propargylimidazoles: Synthesis, structure, antimicrobial activity, AIM analysis and molecular docking

Sterkhova,

Parshina,

Grishchenko

et al. 2024

Polyhedron

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Synthesis, Structure, and Biological Activity of Copper(II), Nickel(II), Cobalt(III), and Iron(III) Coordination Compounds with 2-{2-[(Prop-2-en-1-yl)carbamothioyl]hydrazinylidene}propanoic Acid

Cited by 4 publications

References 19 publications

A new thiosemicarbazone and its 3d metal complexes: Synthetic, structural, and antioxidant studies

A new thiosemicarbazone and its 3d metal complexes: Synthetic, structural, and antioxidant studies

Introducing N‐Heteroaromatic Bases into Copper(II) Thiosemicarbazon Complexes: A Way to Change their Biological Activity

Six-coordinated complexes of Co(II), Ni(II) and Cu(II) chlorides with N-propargylimidazoles: Synthesis, structure, antimicrobial activity, AIM analysis and molecular docking

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