Synthesis, structure and catalase activity of three new manganese(III) complexes with a N,N,O donor Schiff-base ligand

Kar, Paramita; Drew, Michael G. B.; Ghosh, Ashutosh

doi:10.1016/j.ica.2013.06.011

Cited by 22 publications

(5 citation statements)

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“…The N(1)–Mn(1)–N(2) angle is 81.35(9)°, as is expected for a six member chelate . The Mn–N imine distance {2.035(2) Å} is shorter than the Mn–N amine distance {2.391(3) Å}, as is also observed in similar systems …”

Section: Resultssupporting

confidence: 74%

Synthesis, Characterization, DFT Study, Catechol Oxidase and Phenoxazinone Synthase Like Activities of Two New Manganese(IV) Schiff Base Complexes

et al. 2017

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Two manganese(IV) complexes [Mn(L) 2 ](ClO 4 ) 2 ·0.88H 2 O (1) and [Mn(HL) 3-(N,N-dimethylamino)propyliminomethyl-4-bromophenol] have been prepared and characterized. Manganese(IV) in each complex assumes distorted octahedral geometry. Structural features have been examined in detail that reveal the formation of interesting supramolecular networks generated through non-covalent forces including CÀH···p and Br···Br interactions. These interactions have been studied energetically by means of theoretical DFT calculations using several computational tools, including Bader's "atoms-in-molecules" (AIM) theory. Both complexes are found to show catechol oxidase and phenoxazinone synthase like activities.

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Section: Resultssupporting

confidence: 74%

Synthesis, Characterization, DFT Study, Catechol Oxidase and Phenoxazinone Synthase Like Activities of Two New Manganese(IV) Schiff Base Complexes

et al. 2017

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“…The N-Mn-Cl and O-Mn-Cl bond angles, which are larger than 90°, confirm this distortion (table 2). The observed Mn-N, Mn-O and Mn-Cl bond lengths are in the range of previously reported similar complexes[41,42]. The disposition of the Schiff base ligand in the crystal structure of this complex is not planar giving a boat-shaped structure, similar to some of the previously observed related complexes[43,44].…”

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confidence: 88%

New salen-type manganese(III) Schiff base complexes derived from meso-1,2-diphenyl-1,2-ethylenediamine: In vitro anticancer activity, mechanism of action, and molecular docking studies

Damercheli

Dayyani

Behzad

et al. 2015

Journal of Coordination Chemistry

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Four new manganese(III) Schiff base complexes (1-4) were synthesized and characterized. The complexes have general formula [MnClL x ] in which L represents a Schiff base ligand derived from condensation of meso-1,2-diphenyl-1,2-ethylenediamine with salicylaldehyde or its 3-OMe-, 5-Br-or 5-OMe-derivatives (x = 1-4, respectively). The crystal structure of [MnClL 1 ](1) was characterized by X-ray crystallography. The in vitro anticancer activity of these complexes was evaluated by MTT and apoptosis assays against human breast (MCF-7) and liver (Hep G2) cancer cells. The complexes exhibited considerable antiproliferative activity against both cell lines (IC 50 = 10.8-21.02 µM) comparable to cis-platin, except 4 (MCF-7). The highest activity was found for 1 with IC 50 values of 13.62 µM (MCF-7) and 10.8 µM (Hep G2). Flow cytometry experiments showed that 1 induced apoptosis on MCF-7 tumor cell line. Docking simulations using AUTODOCK were also carried out. The results showed that all complexes fitted into the minor groove region of DNA.

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“…[ 25,26 ] Many metal‐based complexes have been used to mimic several enzymes, for example, superoxide dismutase, catalase, and so on. [ 27–30 ]…”

Section: Introductionmentioning

confidence: 99%

“…[25,26] Many metal-based complexes have been used to mimic several enzymes, for example, superoxide dismutase, catalase, and so on. [27][28][29][30] The formation and characteristics of mixed-ligand complexes have received much attention, as they represent new materials for enhancement biological and catalytic features. Thus, based on the aforementioned facts, an attempt has been made to design new mixed-ligand complexes with good biological and catalytic properties.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, structural elucidation, and density functional theory investigation of new mononuclear Fe(III), Ni(II), and Cu(II) mixed‐ligand complexes: Biological and catalase mimicking activity exploration

Abdou

Abdel‐Mawgoud

2022

Applied Organom Chemis

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The present paper deals with synthesis new mononuclear 1:1:1 metal:ligand:co‐ligand complexes, FeLG, NiLG, and CuLG, where L = 1‐{(E)‐[(4‐methylphenyl)imino]methyl}‐2‐naphthol and G = Glycine. The synthesized complexes were characterized based on elemental analysis, Fourier transform infrared spectroscopy (FT‐IR), ultraviolet–visible (UV–vis), mass spectra, molar conductance, magnetic susceptibility, and thermal analysis (TGA) in addition to stoichiometry determination via molar ratio method. The isolated metal complexes showed interesting geometry variation as tetrahedral for CuLG and octahedral for both FeLG and NiLG. The molecular structures of the titled compounds were optimized theoretically using density functional theory (DFT) approach, and the quantum chemical descriptors were calculated. The disk diffusion method was used to investigate the growth inhibition of the titled compounds aganist selected pathogenic bacterial and fungal strains. The metal complexes exhibited higher enhancement as antimicrobial candidates with lower minimum inhibitory concentration (MIC) than the free ligands, and in some cases, the complexes were closed to the standard species. Molecular docking investigation was carried out to ascertain the inhibitory action of the studied compounds against 1HNJ protein, the target enzyme for the antimicrobial agents. The results indicated that the FeLG has the highest binding affinity in comparison with other compounds. Thus, these molecules could be promising antimicrobial candidates. Furthermore, catalase mimicking activity of the complexes has been investigated. The data revealed that CuLG complex catalyzes the decomposition of hydrogen peroxide most effectively. Finally, the quantum chemical parameters of the titled complexes and other different compounds were correlated with their practical biological activity data in a trial to build a SAR model.

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Synthesis, structure and catalase activity of three new manganese(III) complexes with a N,N,O donor Schiff-base ligand

Cited by 22 publications

References 50 publications

Synthesis, Characterization, DFT Study, Catechol Oxidase and Phenoxazinone Synthase Like Activities of Two New Manganese(IV) Schiff Base Complexes

Synthesis, Characterization, DFT Study, Catechol Oxidase and Phenoxazinone Synthase Like Activities of Two New Manganese(IV) Schiff Base Complexes

New salen-type manganese(III) Schiff base complexes derived from meso-1,2-diphenyl-1,2-ethylenediamine: In vitro anticancer activity, mechanism of action, and molecular docking studies

Synthesis, structural elucidation, and density functional theory investigation of new mononuclear Fe(III), Ni(II), and Cu(II) mixed‐ligand complexes: Biological and catalase mimicking activity exploration

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