Synthesis, structure and cytotoxicity of diorganotin(IV) complexes of 2,6-lutidine-α2,3-diol (Lu): The crystal structures of Lu and [SnMe2(H2O)(Lu-2H)]

Synthesis, structure and cytotoxicity studies on diorganotin (R = Me, Et) complexes of N-methylpyridoxine (MePN, PN = Vitamin B6) containing different anions

“…The SneO bond distances to these two O atoms are different. The Sn(1)eO(2) bond distance [2.071(2) Å] is the shortest and is close to those found in 1, 5 and other diorganotin complexes in which the tin is bonded to a deprotonated phenolic O atom [2, 3,5,8]. On the other hand, the SneO(1) bond distance (2.520 Å) is longer but is close to (or shorter than) the values found for alcohol complexes of tin [19], shorter than the sum of the Van der Waals radii of O and Sn (3.70 Å) [14] and in the range of bond distances that are typical of a SneO bond [15,16].…”

“…The behavior of both compounds is similar in that they are less active against A2780cis than A2780 cells [in fact, the values of RF ¼ IC 50 (A2780cis/IC 50 A2780) are 6.4 and 7.2 for 7$2H 2 O and cisplatin, respectively]. This behavior is in contrast to that of [SnBu 2 (PN-2H)] and [SnBu 2 (Lu-2H)], which have values [5] of 1.0 and 2.45, respectively. Against the HeLa-229 line exhibit IC 50 values in line with other diorganotin complexes [28] but slightly worse than that of cisplatin.…”

“…In the first class, which includes 1, 5 The O(1) and O(1) #1 atoms bridging between two Sn atoms form a Sn 2 O 2 planar ring. This ring is similar to those previously found in diorganotin compounds with N-protonated or N-methylated pyridoxine [2, 3,8].…”

“…These reactions allowed the isolation of compounds containing monodeprotonated PN-H (I) or dideprotonated PN-2H (II) pyridoxine as ligands. Additionally, we reacted [3] PN with SnR 2 O in toluene/ethanol to obtain the dideprotonated [SnR 2 (PN-2H)] 2 pyridoxine complexes (R ¼ Me, Et, Bu), the butyl derivative of which showed interesting antitumoral activity against some cellular lines [4,5]. N-Methylpyridoxine (MePN, III, Scheme 1) lacks the biological activity of PN [6] but was identified as a urinary metabolite of vitamin B 6 [7].…”

New diorganolead(IV) sulfanylpropenoates: Synthesis, characterization and analysis of their evolution in DMSO solution

“…However, the dimethyllead(IV) compounds are more fragile in DMSO than the diphenyllead(IV) ones, as the 1 H NMR measurements indicated, and decompose very quickly. As was pointed out before [1g], the decomposition might be due to the known tendency of the dialkyllead(II) compounds to undergo redistribution reactions [17] leading to the formation of trimethyl-and tetramethyllead(IV), and also Pb(II). The signals of these new organometallic moieties become clearly visible in the 1 H NMR spectra shortly with time, and the same happens with the signals corresponding to the decomposition of the sulfanylpropenoates.…”