Synthesis, Structure and Gastric H⁺/K⁺-ATPase Inhibitory Activities of Bisabolonalone Hydrazone Carboxamides

Abstract

Five novel bisabolonalone hydrazone carboxamides were synthesized as potential anti-ulcer agents. Their structures were characterized by NMR, IR and ESI-MS. All of the compounds possessed the better H+/K+-ATPase inhibitory activity than the commercial omeprazole with the IC50 of 18~68 μM in vitro. These compounds could be potentially use for the treatment of ulcer related diseases.