Synthesis, structure and in vitro antiproliferative effects of alkyne-linked 1,2,4-thiadiazole hybrids including erlotinib- and ferrocene-containing derivatives

Abstract

Fourteen 1,2,4-thiadiazole derivatives were synthesized and structurally characterized; their in vitro antiproliferative activities were evaluated on four tumorous cell lines (U87, A2058, A431, and HepG2).