Synthesis, structure and in vitro anticancer activity of ruthenium(II) and platinum(II) complexes with chiral aminophosphine ligands

Sarı, Özlem; Schüttler, Anna; Lönnecke, Peter; Bednarski, Patrick J.; Hey‐Hawkins, Evamarie; Karakuş, Mehmet

doi:10.1007/s11243-020-00446-0

Cited by 7 publications

(1 citation statement)

References 43 publications

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“…Figure 3 shows the ORTEP view of Ru3 as a representative complex of the series. The structure shows the characteristic "three-legged piano-stool" conformation around the Ru center with a η 6 -coodinated p-cymene ring [48,49]. Its solid-state structure revealed a distorted tetrahedral geometry with a P-Ru-P chelate angle of 68.42(13) • .…”

Section: Synthesis and Characterization Of Precursor Ligands And Ruthenium Compoundsmentioning

confidence: 99%

Tuning the Cytotoxicity of Bis-Phosphino-Amines Ruthenium(II) Para-Cymene Complexes for Clinical Development in Breast Cancer

et al. 2021

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Despite some limitations such as long-term side effects or the potential presence of intrinsic or acquired resistance, platinum compounds are key therapeutic components for the treatment of several solid tumors. To overcome these limitations, maintaining the same efficacy, organometallic ruthenium(II) compounds have been proposed as a viable alternative to platinum agents as they have a more favorable toxicity profile and represent an ideal template for both, high-throughput and rational drug design. To support the preclinical development of bis-phoshino-amine ruthenium compounds in the treatment of breast cancer, we carried out chemical modifications in the structure of these derivatives with the aim of designing less toxic and more efficient therapeutic agents. We report new bis-phoshino-amine ligands and the synthesis of their ruthenium counterparts. The novel ligands and compounds were fully characterized, water stability analyzed, and their in vitro cytotoxicity against a panel of tumor cell lines representative of different breast cancer subtypes was evaluated. The mechanism of action of the lead compound of the series was explored. In vivo toxicity was also assessed. The results obtained in this article might pave the way for the clinical development of these compounds in breast cancer therapy.

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Section: Synthesis and Characterization Of Precursor Ligands And Ruthenium Compoundsmentioning

confidence: 99%

Tuning the Cytotoxicity of Bis-Phosphino-Amines Ruthenium(II) Para-Cymene Complexes for Clinical Development in Breast Cancer

et al. 2021

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Synthesis, structure and biological evaluation as antibacterial agents of Ru(II)-p-cymene-aryldicyclohexylphosphine complexes

do Rosario,

Marszaukowski,

Dimbarre Lao Guimarães

et al. 2023

Inorganica Chimica Acta

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Evaluation of heteroscorpionate ligands as scaffolds for the generation of Ruthenium(II) metallodrugs in breast cancer therapy

Domínguez-Jurado,

Ripoll,

Lara-Sánchez

et al. 2024

Journal of Inorganic Biochemistry

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Synthesis, structure and in vitro anticancer activity of ruthenium(II) and platinum(II) complexes with chiral aminophosphine ligands

Cited by 7 publications

References 43 publications

Tuning the Cytotoxicity of Bis-Phosphino-Amines Ruthenium(II) Para-Cymene Complexes for Clinical Development in Breast Cancer

Tuning the Cytotoxicity of Bis-Phosphino-Amines Ruthenium(II) Para-Cymene Complexes for Clinical Development in Breast Cancer

Synthesis, structure and biological evaluation as antibacterial agents of Ru(II)-p-cymene-aryldicyclohexylphosphine complexes

Evaluation of heteroscorpionate ligands as scaffolds for the generation of Ruthenium(II) metallodrugs in breast cancer therapy

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