Synthesis, structure and properties of two series of platinum(II) complexes containing methyleugenol or chelating methyleugenol and amine

Synthesis, structure, and in vitro cytotoxicity of organoplatinum(II) complexes containing aryl olefins and quinolines

“…For example, safrole (in sassafras oil) and methyleugenol (in lemongrass, tarragon oils) were introduced into the coordination sphere of Pt(II). Then, under mild reaction conditions these aryl olefin ligands were deprotonated to form new platinacycles [12][13][14]. It is interesting that many of these organoplatinum (II) complexes exhibit significant inhibitory activities on human cancer cells, in which the complexes containing heterocyclic amines have high activity (IC 50 = 2.5-5.0 μg mL −1 ).…”

Crystal structures of three platinacyclic complexes bearing isopropyl eugenoxyacetate and pyridine derivatives

“…Although platinum-based drugs have dominated the treatment of various cancers by chemical agents, the research on new platinum(ll) complexes for the purpose of medical application is still attractive for the worldwide scientific society (Johnstone et al, 2016). Recently, numerous platinum(ll) complexes bearing alkene and pyridine derivatives have been synthesized and tested for their anti-cancer activities (Bigioni et al, 2000;Da et al, 2012Da et al, , 2015Chi et al, 2017Chi et al, , 2018Cucciolito et al, 2018;Dodoff et al, 2012). Nevertheless, crystal data for these complexes are limited, some examples being the crystal structures of [PtCl(eugenol-1H)(pyridine)], [PtCl(eugenol-1H)(4-methylpyridine)] (Chi et al, 2018) and trans-[PtCl 2 (C 2 H 4 )(N-3-pyridinylmethanesulfonamide)] (Dodoff et al, 2012).…”

Crystal structure of chlorido{4,5-dimethoxy-2-[(2,3-η)-2-prop-2-en-1-yl]phenyl-κC1}(piperidine-κN)platinum(II) ethanol monosolvate

“…Methyleugenol is used as a fruit-fly attractant in agriculture (Todd et al, 2008) and in the formulation of UV absorbers, analgesics, and psychotropic drugs in medicine (Darshan & Doreswamy, 2004;Freeman & Alder, 2002). Platinum(II) complexes containing methyleugenol of formula [PtCl 2 (Meug)(Amine)] and deprotonated methyleugenol of formula [PtCl(Meug-1H)(Amine)] have been described in very few works (Da et al, 2007(Da et al, , 2010(Da et al, , 2015. It is interesting that some of these complexes exhibit strong activities on human cancer cells KB with IC 50 = 3.2-3.7 mg/mL (Da et al, 2015).…”

“…Platinum(II) complexes containing methyleugenol of formula [PtCl 2 (Meug)(Amine)] and deprotonated methyleugenol of formula [PtCl(Meug-1H)(Amine)] have been described in very few works (Da et al, 2007(Da et al, , 2010(Da et al, , 2015. It is interesting that some of these complexes exhibit strong activities on human cancer cells KB with IC 50 = 3.2-3.7 mg/mL (Da et al, 2015). Based on these observations and prompted by the fact that one of our research areas focuses on the design and synthesis of compounds with high biological activity starting from inexpensive natural products, we have prepared the title compound [PtCl(Meug-1H)(Piperidine)] and determined its crystal structure.…”