Synthesis, Structure, and Properties of 2-Oxo-3-formylquinolone Acylhydrazone Containing a Trimethylammonium Fragment and also of Transition Metal Complexes Based on This Compound

Попов, Л. Д.; Tupolova, Yu. P.; Власенко, В. Г.; Бородкин, С. А.; Левченков, С. И.; Lebedev, Vladimir E.; Askalepova, O. I.; Бородкин, Г. С.; Зубенко, А. А.; Gishko, K. B.; Zubavichus, Yan V.; Лазаренко, В. А.; Shcherbakov, I. N.

doi:10.1134/s1070363222120301

Cited by 2 publications

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“…73 The electronic spectrum of Au (III), Pt (II), and Pd (II) complexes with (GT.O) in a Nujol mull showed the same transitions because they are all in the d 8 spin state. The Pt (II) complex has a low-spin d 8 system and is diamagnetic. The allowed d-d transitions can be seen at 522-552 nm, 480-436 nm, and 402-336 nm co to 1 A 1g !…”

Section: Structural Characterization Of the Ligands And Complexesmentioning

confidence: 99%

“…Although the Girard‐T reagent has been widely known for a long period, 4–7 metal‐ion complexes with Girard‐T reagent‐based ligands are relatively unusual. These substances and their derivatives are employed in pharmacological research such as protistocidal 8 and antimicrobial activities 9–11 . Moreover, metal complexes of Girard‐T and hydrazone moieties have cytotoxic activity against malignant cancer cell lines 12,13 .…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, spectroscopic, molecular docking, theoretical calculations, DNA‐binding, and anticancer activity studies of gold (III), platinum (II), palladium (II), and ruthenium (III) complexes with Girard‐T reagent

Al‐Radadi,

El‐Gamil

2023

Applied Organom Chemis

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This article details the synthesis of new Girard‐T reagent ligands. Condensation of 2‐hydroxyacetophenone or 2‐acetyl‐thiophene with Girard‐T reagent results in new hydrazone ligands. The interaction of these Girard‐T hydrazones with transition metal chlorides, like Au (III), Ru (III), Pd (II), and Pt (II), produces different complexes. Elements and spectrum analyses (IR, UV–Vis, EI‐mass, and 1H NMR) were used to characterize the isolated solid complexes, as well as conductimetric and magneto‐chemical studies. Metal complexes can have different geometrical configurations, including square planar and octahedral coordination. The DMOL3 method, which is a part of the Material Studio package, was also utilized for structure optimization. Horowitz–Metzger and Coats–Redfern methods were utilized to calculate the various thermodynamic and kinetic parameters. The ligands and the complexes of their metal were evaluated for anticancer activity against carcinoma cervix (Prostate) and the mammary gland female breast (MCF‐7) cell line having cancer, with promising results. Among these compounds, the Ru (III) and Pt (II) complexes' anticancer activity against (MCF‐7) cell lines, comparable with that of 5‐fluorouracil were carried out and their interactions were performed by molecular docking simulations against MCF‐7 (PDB ID: 3W2S) receptor.

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Section: Structural Characterization Of the Ligands And Complexesmentioning

confidence: 99%