Synthesis, structure characterization and biological activity of selected metal complexes of sulfonamide Schiff base as a primary ligand and some mixed ligand complexes with glycine as a secondary ligand

Metal complexes of novel Schiff base derived from iron sandwiched organometallic and 4‐nitro‐1,2‐phenylenediamine: Synthesis, characterization, DFT studies, antimicrobial activities and molecular docking

“…The highest inhibition ratio value (74%) corresponding to Cd(II) complex. Also the relationship between drug concentration and cell viability was plotted to calculate IC 50 (μg/ml) (the value which corresponds to the concentration required for 50% inhibition cell viability) . Furthermore, four concentrations (0, 12.5, 25 and 50 μg/ml) and the IC 50 values of more active complexes with inhibition ratio value >70% were measured and listed in Table and Figure .…”

Biological and catalytic potential of sustainable low and high valent metal-Schiff base sulfonate salicylidene pincer complexes

“…26 Currently, there are many published literatures reporting the anticancer activities of various transition metal Schiff base complexes, Abd El-Halim et al 27 studied the Cr 2+ , Fe 2+ , Mn 2+ , Cu 2+ , Cd 2+ , Co 2+ and Ni 2+ -1,10-phenanthroline-Schiff base complex as high antimicrobial and anticancer reagents. The antimicrobial and anticancer activity of Bi 3+ , Pb 2+ , Cr 3+ , Cu 2+ , Cd 2+ , Ba 2+ , Ni 2+ , Fe 2+ , Nd 2+ and Sn 2+ -Schiff base complexes are studied by Sheng et al 28 and Sharaby et al 29 They investigated the microbial and anticancer potentials of sulfonamide imine and mixed coordinated ligand complexes with glycine spectroscopically. Mahmoud et al published many biological studies of bidentate Schiff base ferrocene metal complexes derived from amino acids.…”

Synthesis, Spectroscopic Characterization And Antimicrobial Evaluation of Novel Nitrogen Containing Metal Complexes

“…Schiff bases are azomethine group (C=N) containing compounds which were first announced by Hugo Schiff in 1864 and synthesized by condensation of the primary amine with carbonyl compound [1]. Schiff bases remain the most extensively utilized organic compounds [2][3][4][5][6][7] and it has potential sites, such as nitrogen and other electron donors; it may be related to their stability, uses and applications in numerous scientific areas [1,2,4,5,[8][9][10]. For long periods of time, coordination chemistry of Schiff base ligands has been the topic of great interest.…”

“…These compounds are able to form coordination bonds with many metal ions via azomethine group (C=N) and other electron donor groups, so they have been used for the synthesis of metal complexes due to their easy formation and strong ability to bind with metal ions [4][5][6][7][10][11][12][13] and their ability to form stable complexes to use as model compounds in service of biologically important species [12][13][14] where the nitrogen atom of azomethine group may be participated in the formation of constituents and interferes in normal cell processes so the (C=N) bond in azomethine derivatives is essential for biological activities [1,15] as antitumor, antimicrobial agents (antifungal, antibacterial, antiviral and antiparasitic agents) and other biological performances [15]. These compounds have also played a great role in the chemistry development [2,3,5,6,11,16]. These complexes were more widely studied because of their attractive chemical and physical properties and their wide range of applications in numerous scientific areas [15].…”