Synthesis, structure, DNA binding, cleavage and biological activity of cobalt (III) complexes derived from triethylenetetramine and 1,10 phenanthroline ligands

Gopinathan, Harikesavan; Komathi, N.; Arumugham, M. N.

doi:10.1016/j.ica.2014.03.015

Cited by 28 publications

(9 citation statements)

References 45 publications

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“…The drop of the voltammetric currents in the presence of CT-DNA can be attributed to diffusion of the metal complex bound to the large, slowly diffusing DNA molecule. Obviously, E1/2 undergoes a positive shift (25 mV) after forming an aggregation with DNA, suggesting that the copper complex bind to DNA mainly by intercalation binding mode 48 , and this result also proves the results obtained from viscosity and absorption spectrum studies again.…”

Section: Cyclic Voltammetric Studysupporting

confidence: 83%

Synthesis, Characterization, DNA Binding studies and Biological activities of Copper (II) Complexes containing L-Ornithine, 2,2’ - bipyridyl and Urea & Thiourea

2020

JCBSC

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Ternary copper(II) complexes [Cu(bipy)(L-Orn)U] ClO4 1 & [Cu(bipy)(L-Orn)TU] ClO4 2 (bipy = 2,2'-bipyridyl, L-Ornithine, U= Urea and TU = Thiourea), have been synthesized and characterized by CHN analysis, molar conductance, electronic absorption, IR and EPR spectral studies. They have been tested for their in vitro DNA binding activities by the spectroscopic methods such as UV-Visible, Cyclic volumetric and viscosity measurement. Further complexes 1 & 2 were tested for their antimicrobial activities and it was found to have good antimicrobial activities.

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Section: Cyclic Voltammetric Studysupporting

confidence: 83%

Synthesis, Characterization, DNA Binding studies and Biological activities of Copper (II) Complexes containing L-Ornithine, 2,2’ - bipyridyl and Urea & Thiourea

2020

JCBSC

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“…The filtrate was kept for slow evaporation, after two weeks bluish green complex was separated out. The DNA binding and antimicrobial activity experimental details were given in literature [19] .…”

Section: Synthesis Of [Cu(l-met)(phen)(ea)](no 3 ) (1)mentioning

confidence: 99%

Synthesis, characterization and DNA binding of copper(II) complexes with mixed ligands of 1, 10-phenanthroline / 2-2’ bipyridyl, L-methionine and ethylamine: Studies on antimicrobial and anti-cancer activities

Ezhilarasan¹,

Krishnan²,

Arumugham³

2017

Int. J. Curr. Res. Chem. Pharm. Sci

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Ternary copper(II) complexes [Cu(phen)(L-met)EA)] 1 & [Cu(Bpy)(L-met)EA] 2 ( phen = 1,10-phenanthroline Bpy = bipyridyl, LMethionine and EA= Ethylamine), have been synthesized and characterized by CHN analysis, molar conductance, electronic absorption, IR and EPR spectral studies. They have been tested for their in vitro DNA binding activities by the spectroscopic methods such as UV-Visible, Cyclic volumetric and viscosity measurement. Further, complexes 1 and 2 displayed significant cytotoxicity when examined in-vitro on a panel of cancerous cell line -human liver cancer cell line -HepG-2 cells (IC50= 40.82 and 29.74 μg/ml). Further complexes 1 & 2 were tested for their antimicrobial activities and it was found to have good antimicrobial activities.

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“…The complex [Cu(phen)(L-val)(H 2 O)](NO 3 ) was synthesized according to a published method 20 The detailed experimental setup of DNA binding, MTT assay and antimicrobial activity described in the literature 21 .…”

Section: Synthesis Of [Cu(phen)(l-valine)tu]no 3 (1)mentioning

confidence: 99%

“…After the incubation period, MTT assay was carried out to calculate the cell death percentage. For each concentration, of the complexes, cells were incubated in triplicate 21 . Fig.…”

Section: Cyclic Voltammetric Studiesmentioning

confidence: 99%

Untitled

2019

IJPSR

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This article describes the Cu(II) complexes including [Cu(phen)(L-val)TU)] 1 & [Cu(bpy)(L-val)TU)] 2 (phen = 1, 10-phenanthroline; bpy = 2,2'-bipyridyl, L-val = L-valine and TU = Thiourea). The complexes were synthesized by ligand substitution method and characterized by various physicochemical techniques. The intense UV band around 270 nm was due to nπ* transition. The binding behaviors of these complexes to cal thymus DNA (CT-DNA) were explored by spectroscopic titrations, emissions, viscosity measurements, and cyclic voltammetry. The binding constant value of complexes 1 and 2 was 8.42 × 10 5 M -1 and 7.12 × 10 5 M -1 respectively. Results suggest that the complex 1 can bind to CT-DNA through intercalation and complex 2 binds through partial intercalation. However, their binding ability differed, this may be attributed to the difference in ligand coordinated the metal centre, complex 1 shows higher binding affinity than complex 2, this is due to the extended π-conjugated system of phenanthroline ring. The cytotoxicity of complexes 1 and 2 evaluated by MTT assay; results indicated that complexes have significant cytotoxicity with HePG2 tumor cell line.

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Synthesis, structure, DNA binding, cleavage and biological activity of cobalt (III) complexes derived from triethylenetetramine and 1,10 phenanthroline ligands

Cited by 28 publications

References 45 publications

Synthesis, Characterization, DNA Binding studies and Biological activities of Copper (II) Complexes containing L-Ornithine, 2,2’ - bipyridyl and Urea & Thiourea

Synthesis, Characterization, DNA Binding studies and Biological activities of Copper (II) Complexes containing L-Ornithine, 2,2’ - bipyridyl and Urea & Thiourea

Synthesis, characterization and DNA binding of copper(II) complexes with mixed ligands of 1, 10-phenanthroline / 2-2’ bipyridyl, L-methionine and ethylamine: Studies on antimicrobial and anti-cancer activities

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