Synthesis, Structure Elucidation and Study of Antimicrobial Activity of Stannic(IV) Derivatives

Abstract

Organotin compounds are of current interest due to increase in their biological activities as well as industrial and agricultural applications 1,2 . There are now more organometallic compounds of tin in commercial use than any other element, covering a wide spectrum of biological and non-biological applications 3,4 . In general, the biochemical activity of organotin compounds is influenced remarkably by the coordination number of tin atoms 5 . Among organotin(IV) compounds, organotin(IV) carboxylates have been studied extensively for their antimicrobial, antiinflammatory and antituberculosis activities 5 . In view of well known application and biological activities of organotin derivatives we are continuously involved in synthesis and characterization of organotin(IV) carboxylates [6][7][8] .Recently, we have investigated organotin compounds containing alkoxide ligand 4-hydroxypiperidine with di-and triorganotin moieties and the result of this study are reported here in. EXPERIMENTALAnalytical grade organotin chlorides (dimethyltin dichloride, trimethyltin chloride, triphenyltin chloride, diphenyltin dichloride, tri-n-butyltin chloride, di-n-butyltin dichloride) were purchased from Aldrich. The ligand, 4-hydroxypiperidine was obtained from ACROS. Organic solvents used for synthesis

Antimicrobial and Cytotoxicity Studies of Some Organotin(IV) N-ethyl-N-phenyl Dithiocarbamate Complexes

“…However, their main group counterparts such as tin are less explored. Among the few that have been reported, organotin(IV) dithiocarbamate complexes have shown to have useful biological potential [8][9][10][11]. The dithiocarbamate group, the organotin moiety, and the coordination number of the central metal in these complexes play important roles in determining their usefulness as biological agents [12].…”