Synthesis, Structure Elucidation, Antioxidant and Antimicrobial Activity of Novel 2-(5-Trifluoromethyl-1H-pyrazol-1-yl)-5-(5-trihalomethyl-1H-pyrazol-1-yl-1-carbonyl)pyridines

Biologically important hydrazide-containing fused azaisocytosines as antioxidant agents

“…Furthermore, the range of thermal stability of carbohydrazide-bearing compounds, a mechanism of thermal decomposition and major decomposition products of some of the most active and selective agents with prospective medical use have been determined and described recently [20]. However, IR, 1 H NMR and 13 UV spectra of the examined hydrazide-containing fused azaisocytosines Absorption band maxima in the ultraviolet region of electronic spectra of all the hydrazide-containing compounds (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11) were determined on U2800 Hitachi spectrophotometer (Japan).…”

“…The nitric oxide radical scavenging abilities of the hydrazide-containing fused azaisocytosines (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11) and antioxidant standards at different concentrations are shown in Table 2 and Figure 4. The antiradical activities are expressed as the per cent of NO scavenging effect as well as IC 50 values.…”

“…Therefore, the balance between the formation and removal of different types of ROS in the body is kept under strict control by several cellular and extracellular mechanisms. Antioxidants are capable of stabilising or neutralising free radicals before they attack the biological targets in the cell system, hence protecting the molecules from oxidative damage [5]. It is a well-known fact that antioxidants, by acting as free radical scavengers, may be an efficient weapon in the prevention and treatment of many widespread diseases (i.e.…”

“…For this reason, the design and synthesis of small molecules are directed towards the search and identification of new agents with antioxidant activity to combat cellular oxidative stress. An antioxidant therapy appears as a tool to minimise the molecular damages of vital constituents of living organisms caused by ROS and therefore the search for antioxidant agents has significantly increased during the past decades [3][4][5][6].…”

“…Menteşe et al [10,11] have found that 2-substituted benzimidazol-1ylacetohydrazides reveal remarkable radical scavenging activities. Khan et al [12] have disclosed 3-propylpyrazole-5carbohydrazide as the anticipated drug candidate with the highest antioxidant properties in the class of hydrazide-containing pyrazoles, whereas Bonacorso et al [5] have confirmed antioxidant properties of 6-pyrazolylhydrazides of nicotinic acid. Furthermore, Hadjipavlou-Litina et al [13] have proposed inter alia 1-H-indol-3-ylpropanoic acid hydrazide as a molecule with prospective utility in the treatment and prevention of a neurodegenerative disorder (such as Alzheimer's disease) due to its significant antioxidant activities.…”