Synthesis, surface modification, and applications of magnetic iron oxide nanoparticles

Ling, Wenhui; Wang, Mingyu; Xiong, Chunxia; Xie, Deng-Feng; Chen, Qiyu; Chu, Xinyue; Qiu, Xiaoyan; Li, Yuemin; Xiao, Xiong

doi:10.1557/jmr.2019.129

Cited by 78 publications

(38 citation statements)

References 79 publications

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“…Moreover, they were investigated as carriers for active agents for drug targeting [6]. In the last few decades, several studies showed the development of preparations containing IOMNP to be used for in vitro separation, tissue repair, cellular therapy, magnetic separation, magnetic resonance imaging, as spoilers for magnetic resonance spectroscopy, in drug delivery, hyperthermia, sensors for metabolites, and other biomolecules [6,11,12,16,18,30,[32][33][34][35].…”

Section: Iron Oxides and Nanoparticlesmentioning

confidence: 99%

“…These nanoparticles possess very important characteristics, such as superparamagnetism, size, and the possibility of receiving a biocompatible coating. Therefore, ongoing researches are focused on reducing drug concentration, toxicity, and other side effects, and improving the therapy [6,18,21,32].…”

Section: Pharmaceutical Applicationsmentioning

confidence: 99%

“…However, more toxicological clinical investigations about IOMNPs are necessary.Since the early 1960s, metal oxides were used for magnetic separations [3,16]. Specifically, nanoparticles composed of iron oxide attracted great interest for pharmaceutical applications [1,[3][4][5][6]11,12,17,18]. This mineral compound shows different polymorphic forms, such as hematite, magnetite, and maghemite [19].…”

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confidence: 99%

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Pharmaceutical Applications of Iron-Oxide Magnetic Nanoparticles

Bruschi

Toledo

2019

Magnetochemistry

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Advances of nanotechnology led to the development of nanoparticulate systems with many advantages due to their unique physicochemical properties. The use of iron-oxide magnetic nanoparticles (IOMNPs) in pharmaceutical areas increased in the last few decades. This article reviews the conceptual information about iron oxides, magnetic nanoparticles, methods of IOMNP synthesis, properties useful for pharmaceutical applications, advantages and disadvantages, strategies for nanoparticle assemblies, and uses in the production of drug delivery, hyperthermia, theranostics, photodynamic therapy, and as an antimicrobial. The encapsulation, coating, or dispersion of IOMNPs with biocompatible material(s) can avoid the aggregation, biodegradation, and alterations from the original state and also enable entrapping the bioactive agent on the particle via adsorption or covalent attachment. IOMNPs show great potential for target drug delivery, improving the therapy as a consequence of a higher drug effect using lower concentrations, thus reducing side effects and toxicity. Different methodologies allow IOMNP synthesis, resulting in different structures, sizes, dispersions, and surface modifications. These advantages support their utilization in pharmaceutical applications, and getting suitable drug release control on the target tissues could be beneficial in several clinical situations, such as infections, inflammations, and cancer. However, more toxicological clinical investigations about IOMNPs are necessary.

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Section: Iron Oxides and Nanoparticlesmentioning

confidence: 99%

Section: Pharmaceutical Applicationsmentioning

confidence: 99%

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confidence: 99%

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Pharmaceutical Applications of Iron-Oxide Magnetic Nanoparticles

Bruschi

Toledo

2019

Magnetochemistry

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“…Magnetic nanoparticles (NPs) are one of the most fascinating nanomaterials with versatile applications, particularly in magnetic data storage, magnetic resonance imaging, magnetic uids, biotechnology/biomedicine, high performance inductors, catalysis and environmental remediation. [2][3][4] The environmental water pollution caused by inorganics (metal ions), and synthetic organic compounds or their degradation products, such as phenols, organochlorines, polycyclic aromatic hydrocarbon, pesticides, polychlorinated biphenyl, polymers and synthetic dyes, is a great challenge of the modern world due to their persistent nature and ultimate detrimental effects on humans and other living organisms. 5 Synthetic dyes are frequently used (0.7 million tons of about 100 000 different kinds per year) in different industries, including the food, cosmetics, leather, pharmaceutical, paper, plastic and textile industries.…”

Section: Introductionmentioning

confidence: 99%

“…This application of magnetic NPs is associated with their dominant features of reduced size (high surface area), low cost, easy and quick magnetic separation, fast reactivity, high environmental stability and adsorption capacity, easy surface functionalization and low biotoxicity. 2,15 Magnetic nanoparticles of the ferrite group are of current research interest due to their wide range of industrial, biomedical and environmental applications. 3,16,17 Cobalt-ferrite is an efficient member of the ferrite family with dominant properties such as chemical stability, high mechanical stability, wear resistance, high anisotropy and medium saturation magnetization.…”

Section: Introductionmentioning

confidence: 99%