Synthesis, toxicity evaluation and determination of possible mechanisms of antimicrobial effect of arabinogalactane-capped selenium nanoparticles

Lesnichaya, M. V.; Perfileva, А. I.; Ножкина, О. А.; Gazizova, Anastasia; Граскова, И. А.

doi:10.1016/j.jtemb.2021.126904

Cited by 20 publications

(15 citation statements)

References 62 publications

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“…The antibacterial mechanisms of selenium nanoparticles follow various pathways. Particularly, arabinogalactane-capped SeNPs could disrupt the integrity of the cell membrane and cause a cellular respiratory reduction due to the inhibition of dehydrogenase enzyme in phytopathogen Clavibacter michiganensis sepedonicus (Cms) [73]. In another report, chemically-synthesized SeNPs stabilized by polyvinyl alcohol could inhibit methicillin-sensitive and methicillin-resistant Staphylococcus aureus through triggering a significant decrease in adenosine triphosphate (ATP) level, promoting ROS production inside bacterial cells, and causing a rupture of cell membranes [74].…”

Section: Discussionmentioning

confidence: 99%

Therapeutic potential of electron beam and gamma irradiation synthesized selenium nanoparticles for health care

Kiet,

Thi Bich Ngoc,

Thi Thanh Ngoc

et al. 2023

Mater. Res. Express

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Selenium nanoparticles (SeNPs) attract more and more interest due to good bioavailability and low toxicity, accompanied by various bioactivities consisting of antimicrobial, antioxidant, and anticancer activity. SeNPs could be generated by physical, chemical, or biological methods and their potential depends on the particle diameter, homogeneity, coating agents, etc Up to now, there has been no previous work reporting on the activities of SeNPs produced by electron beam yet. In our work, SeNPs created by electron beam (SeNP/EB) or gamma irradiation (SeNP/G), stabilized by gum arabic were evaluated for the anticancer capacity by MTT assay, the antioxidant activity by DPPH radical scavenging assay, and the antibacterial ability by agar well diffusion assay. The results showed that SeNP/EB and SeNP/G displayed growth inhibition on HeLa cervical cancer cells with IC50 values of 2.83 and 1.54 μg ml−1, while the values on MCF7 breast cancer cells were 27.70 and 38.80 μg ml−1 respectively. The SeNPs affected HeLa cancer cells more selectively than normal fibroblasts as evidenced by the high selectivity index of 7.98 and 26.25. Notably, the results demonstrated that SeNP/G is much safer than SeNP/EB when applying for cancer treatment in the future. Regarding the DPPH assay, SeNPs of both synthetic methods exhibited potential IC50 values (13.5 and 12 μg ml−1) compared with that of ascorbic acid (8.4 μg ml−1). In comparison to previous studies, our results sugessted that gamma and electron beam irradiation methods, accompanied by coating with gum arabic could be novel approaches in SeNP synthesis to enhance the antioxidant activity of the SeNPs. Besides, SeNPs also caused an inhibition towards Listeria monocytogenes and Escherichia coli, which was verified by the inhibition-zone diameter of approximately 8–12 mm, through inducing oxidative stress in bacterial cells. In conclusion, along with the advantages of physical methods such as time-saving, eco-friendly processes, SeNPs in our work could be a promising candidate for the research and development of healthcare products.

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Section: Discussionmentioning

confidence: 99%

Therapeutic potential of electron beam and gamma irradiation synthesized selenium nanoparticles for health care

Kiet,

Thi Bich Ngoc,

Thi Thanh Ngoc

et al. 2023

Mater. Res. Express

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“…Additionally, SeNPs cause oxidative damage to bacterial cells [58]. SeNPs have been proven to impair cellular respiration and decrease transmembrane potential by affecting the integrity of the cell membrane and blocking the function of enzymes crucial to bacterial growth and metabolism, such as dehydrogenases [59].…”

Section: Discussionmentioning

confidence: 99%

Biogenic Selenium Nanoparticles: Anticancer, Antimicrobial, Insecticidal Properties and Their Impact on Soybean (Glycine max L.) Seed Germination and Seedling Growth

Abdelsalam,

El-Sayed,

Hamama

et al. 2023

Biology

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Selenium nanoparticles (SeNPs) have demonstrated significant potential in a variety of disciplines, making them an extremely desirable subject of research. This study investigated the anticancer and antibacterial properties of my-co-fabricated selenium SeNPs, as well as their effects on soybean (Glycine max L.) seeds, seedling growth, cotton leafworm (Spodoptera littoralis) combat, and plant pathogenic fungi inhibition. SeNPs showed anticancer activity with an IC50 value of 1.95 µg/mL against MCF-7 breast adenocarcinoma cells. The myco-synthesized SeNPs exhibited an antibacterial effect against Proteus mirabilis and Klebsiella pneumoniae at 20 mg/mL. The use of 1 µM SeNPs improved soybean seed germination (93%), germination energy (76.5%), germination rate (19.0), and mean germination time (4.3 days). At 0.5 and 1.0 µM SeNPs, the growth parameters of seedlings improved. SeNPs increased the 4th instar larval mortality of cotton leafworm compared to control, with a median lethal concentration of 23.08 mg/mL. They inhibited the growth of Fusarium oxysporum, Rhizoctonia solani, and Fusarium solani. These findings demonstrate that biogenic SeNPs represent a promising approach to achieving sustainable progress in the fields of agriculture, cancer therapy, and infection control.

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“…The most commonly used precursors are SeO 2 , Na 2 SeO 3 , NaHSeO 3 and H 2 SeO 3 [121][122][123][124]. Less-common precursors are H 2 Se, Na 2 SeO 4 , SeCl 4 or cyclo-octeno-1,2,3-selenadiazole [125][126][127][128].…”

Section: Synthesis Methods Of Selenium Nanoparticlesmentioning

confidence: 99%

A Review of the Antibacterial, Fungicidal and Antiviral Properties of Selenium Nanoparticles

Serov,

Khabatova,

Vodeneev

et al. 2023

Materials

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The resistance of microorganisms to antimicrobial drugs is an important problem worldwide. To solve this problem, active searches for antimicrobial components, approaches and therapies are being carried out. Selenium nanoparticles have high potential for antimicrobial activity. The relevance of their application is indisputable, which can be noted due to the significant increase in publications on the topic over the past decade. This review of research publications aims to provide the reader with up-to-date information on the antimicrobial properties of selenium nanoparticles, including susceptible microorganisms, the mechanisms of action of nanoparticles on bacteria and the effect of nanoparticle properties on their antimicrobial activity. This review describes the most complete information on the antiviral, antibacterial and antifungal effects of selenium nanoparticles.

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Synthesis, toxicity evaluation and determination of possible mechanisms of antimicrobial effect of arabinogalactane-capped selenium nanoparticles

Cited by 20 publications

References 62 publications

Therapeutic potential of electron beam and gamma irradiation synthesized selenium nanoparticles for health care

Therapeutic potential of electron beam and gamma irradiation synthesized selenium nanoparticles for health care

Biogenic Selenium Nanoparticles: Anticancer, Antimicrobial, Insecticidal Properties and Their Impact on Soybean (Glycine max L.) Seed Germination and Seedling Growth

A Review of the Antibacterial, Fungicidal and Antiviral Properties of Selenium Nanoparticles

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