Synthesis with Docking Studies of Novel Heterocycles as Antimicrobial Agents Utilizing 2-Cyano-N-arylacetamide.

Abstract

2 -CYANO-N-arylacetamide reagent is used in a straight forward synthesis of various interesting nitrogenous heterocycles such as iminocoumarine, thiazole, dihydropyridine and imidazole or benzoimidazole. Molecular docking studies are described to show the most active compounds as antimicrobial agents. Also, Biological testing of these compounds for their antimicrobial activities against some strains of Gram bacteria and strains of fungi has been carried out.

Synthesis and Antimicrobial Evaluation of New 5-Amino-2,3-dihydrophthalazine-1,4-dione Derivatives

“…[19][20][21][22][23][24][25] So, in this work, we try to synthesize some new compounds that may have antimicrobial activity starting from Luminol with consideration of our experience in the synthesis of new organophosphorus and heterocyclic compounds. [26][27][28][29][30][31] Herein we studied the reactions of 5-amino-2,3dihydrophthalazine-1,4-dione (Luminol 1) with organophosphorus reagents, namely phosphonium ylides (2a-e), trialkyl phosphites (3a-c), tris(dialkylamino)phosphines (3d,e), thiating agents as Lawesson, and Japanese reagents (4a,b) to synthesize a series of phthalazine derivatives and evaluate their antimicrobial activities against some bacterial and fungal strains (Figure 2).…”