Synthesis, X-ray crystal structure, DNA binding and Nuclease activity of lanthanide(III) complexes of 2-benzoylpyridine acetylhydrazone

Abstract

Lanthanide(III) complexes of general formula [La(BPAH) 2 (NO 3) 3 ] and [Ce(BPAH) 2 (NO 3)(H 2 O) 2 ] 2NO 3 .H 2 O (where, BPAH = 2-benzoylpyridine acetyl hydrazone), were synthesized and characterized by elemental analysis, molar conductance, IR spectroscopy and single crystal X-ray diffraction and Hirschfeld studies. The central metal ion is 12-coordinate in lanthanum complex and 10-coordinated in the cerium complex. The coordination polyhedra around the lanthanum and cerium were found to have distorted icosahedron and distorted bicapped square antiprism respectively. DNA binding and nuclease activity of these complexes were also investigated in the present work.

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“…The hydroxyl free radical formed in the second step leads to DNA damage. This is consistent with the production of hydroxyl radicals by cuprous ions similar to the well known Fenton reaction 21,22 .…”

Investigation of DNA binding and molecular docking propensity of phthalimide derivatives: in vitro antibacterial and antioxidant assay

“…All the experiments were performed in tris-HCl buffer. The absorption ratio of Ct-DNA in buffer was 1.9:1 at 260 nm which reveals that DNA was possibly absolutely free from protein contamination (Raja et al 2016). Absorption intensity was determined at 260 nm for the investigation of DNA concentration of stock solution using a molar absorption coefficient ε 260 = 6600 L mol −1 cm −1 by UV-visible spectrophotometer (Kumar et al 2016).…”

Structure Variation from One-Dimensional Chain to Three-Dimensional Architecture: Effect of Ligand on Construction of Lanthanide Coordination Polymers

“…These factors therefore have great potential in the synthesis of new luminescent materials. 1,2 Because of the 4f -4f transitions 3,4 in the electronic configuration of lanthanide ions, luminescent properties are forbidden by spin and parity selection rules, and the absorption coefficients of lanthanide ions are very small. It is necessary to design or select coordinated organic ligands acting as metal sensitizers to enhance absorption.…”